Results 201 to 210 of about 100,698 (279)

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Comparison of HE staining and IHC staining of hub genes in lung tissues between the DHCA and the control groups.

Lei Wang (6656), Qingtong Wu (20785253), Yuzuo Lin (22057090), Ziyan Lin (11203275), Guodong Zhong (12248816), Liangwan Chen (759982)   +5 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Functional validation experiment of six hub genes encoding plastid RPs in response to salinity stress.

Mojdeh Akbarzadeh Lelekami (21144101), Mohammad Hadi Pahlevani (21144104), Khalil Zaynali Nezhad (5465219), Keyvan Mahdavi Mashaki (5465222)   +3 more
openalex   +1 more source

Peer Review #2 of "Identification of hub genes and small molecule therapeutic drugs related to breast cancer with comprehensive bioinformatics analysis (v0.1)"

, 2020
Mingqian Hao, Wencong Liu, Chuanbo Ding, Xiaojuan Peng, Yue Zhang, Huiying Chen, Ling Dong, Xinglong Liu, Yingchun Zhao, Xueyan Chen, Sadia Khatoon, Yinan Zheng, R Albulescu, Y Bao, L Wang, L Shi, F Yun, X Liu, Y Chen, C Chen, Y Ren, Y Jia, R Bell, R Barraclough, O Vasieva, F Bray, J Ferlay, I Soerjomataram, R Siegel, L Torre, W-X Chen, L-G Yang, L Xu, -Y, L Cheng, Q Qian, L Sun, Y-L Zhu, Y Chen, J Xue, C Chen, B Yang, Q Xu, F Wu, F Liu, X Ye, X Meng, G Liu, Z Shen, Z Shao, J Wu, C-H Chin, S-H Chen, H-H Wu, C-W Ho, M-T Ko, Lin C-Y, K Cotto, A Wagner, Y-Y Feng, S Kiwala, A Coffman, G Spies, A Wollam, N Spies, O Griffith, Griffith, Y Du, J Gong, X Tian, X Yan, T Guo, M Huang, B Zhang, X Hu, H Liu, Wang, S Forbes, N Bindal, S Bamford, C Cole, C Kok, D Beare, M Jia, R Shepherd, K Leung, A Menzies, D Fu, Y Zhang, H Cui, J Gao, B Aksoy, U Dogrusoz, G Dresdner, B Gross, S Sumer, Y Sun, A Jacobsen, R Sinha, Larsson   +99 more
openalex   +2 more sources

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

RNA sequencing and weighted gene co-expression network analysis uncover the hub genes controlling cold tolerance in Helictotrichon virescens seedlings

, 2022
Mingjun Cheng, Zeyang Pan, Kuoshu Cui, Junjun Zheng, Xuan Luo, Youjun Chen, Tao Yang, Hui Wang, Xiaofeng Li, Yang Zhou, Xiong Lei, Yingzheng Li, Ruizhen Zhang, Muhammad Zafar Iqbal, Ruyu He   +14 more
openalex   +1 more source