Results 91 to 100 of about 12,975,694 (258)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Habituated interaction and social objects [PDF]

, 2013
In this position paper we draw from critical approaches to the concept of habit from cultural theory to argue that considering the sociality of everyday objects might be productive for understanding and designing for habituated interaction within the ...
Brereton, Margot, Robertson, T, Nansen, B, Durick, JI, Robertson, Toni, Brereton, M, Durick, J, Vetere, Frank, Vetere, F, Nansen, Bjorn, Durick, Jeannette   +10 more
core  

Eye-to-eye or face-to-face? Face and head substitution for co-located augmented reality

Frontiers in Virtual Reality
In co-located extended reality (XR) experiences, headsets occlude their wearers’ facial expressions, impeding natural conversation. We introduce two techniques to mitigate this using off-the-shelf hardware: compositing a view of a personalized avatar ...
Peter Kullmann, Theresa Schell, Mario Botsch, Marc Erich Latoschik   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tailored information on alternative fuels: Segmenting future consumers' preferences for information and communication related to alternative fuels

Fuel Communications
Increasing emissions in the mobility sector pose a significant challenge for modern society, contributing extensively to climate change. One promising approach to mitigating these emissions is the development of CO₂-based alternative fuels, which can ...
Julia Offermann, Linda Engelmann, Martina Ziefle   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Designing for Conversational Interaction with Interactive Dance Works [PDF]

, 2011
In this paper we describe ongoing work, which explores the physicality of human-computer interaction in dance works. The use of physical simulations in the interface to connect with the performers and audiences lived experience of the physical world is ...
CLARKSON, D, Johnston, AJ
core  

Multimodal Child-Robot Interaction: Building Social Bonds [PDF]

, 2013
07.01.14 KB. Ok to add published version to spiral, OA paper.For robots to interact effectively with human users they must be capable of coordinated, timely behavior in response to social context.
Cosi, Piero, Belpaeme, TonyTW068020022768090000-0001-5207-7745034899FA-C938-11E5-A139-C70DB5D1D7B1, Demiris, Yiannis, Enescu, Valentin, Neerincx, Mark, Ros-Espinoza, Raquel, Athanasopoulos, Georgios, Hiolle, Antione, Kruijff-Korbayová, Ivana, Belpaeme, Tony, Wood, Rachel, Humbert, Remi, Cuayáhuitl, Heriberto, Cañamero, Lola, Racioppa, Stefania, Read, Robin, Lewis, Matthew, Kiefer, Bernd, Beck, Aryel, Paci, Giulio, Baxter, Paul E, Sommavilla, Giacomo, Baroni, Ilaria, Tesser, Fabio, Nalin, Marco, Looije, Rosemarijn   +25 more
core   +1 more source