Results 91 to 100 of about 1,838,117 (303)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Meta Reinforcement Learning with Latent Variable Gaussian Processes [PDF]
, 2018 Learning from small data sets is critical in many practical applications where data collection is time consuming or expensive, e.g., robotics, animal experiments or drug design.
Deisenroth, Marc Peter +2 more
core +2 more sources
Human-animal interactions at Alaybeyi H��y��k
, 2020 Zooarchaeological data on the faunal remains unearthed from 2016 and 2017 excavations at Alaybeyi H y k have primarily been used to understand the animal-based subsistence practices as well as regular and occasional cultural activities at the site. Various aspects of multi-scale, colorful and complex human-animal relationships and interactions have ...
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The nature of human altruism [PDF]
Some of the most fundamental questions concerning our evolutionary origins, our social relations, and the organization of society are centred around issues of altruism and selfishness.
Ernst Fehr, Urs Fischbacher
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An economic approach to collective management of endemic animal diseases [PDF]
The control of animal diseases is an issue of particular interest in animal production chains. Because of their direct impact on production, animal diseases generate income shortfalls for farmers.
Krebs, Stephane, Rat-Aspert, Olivier
core +1 more source
Offender outcomes of training dogs in prison : the Puppies for Parole program [PDF]
, 2016 Poster and abstract"Puppies for Parole" is a rehabilitation program based on human-animal interaction (HAI) in the prison. Puppies for Parole aims to reduce the number of homeless canines by producing loving, obedient, and adoptable dogs.
Cade, Elliot +6 more
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