Results 91 to 100 of about 1,230,539 (304)

Bestiality, Zoophilia and Human–Animal Sexual Interactions [PDF]

open access: yesParagraph, 2019
From the earliest human cultures, nonhuman animals have been central to the sexual imaginary of humans. This article traces the modern history of bestiality from the nineteenth century, culminating in ‘zoo’ communities today. It explores the changing ideas about the ‘wrongness’ of such acts. It asks: what do human–animal sexual relations tell us about
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Following the animal : Place, space and literature [PDF]

open access: yes, 2018
"Nonhuman animals are ubiquitous to our 'human' societies. Interdisciplinary human/animal research has - for 50 years - drawn attention to how animals are ever-present in what we think of as human spaces and cultures. Our societies are built with animals
Lönngren, Ann-Sofie,
core  

Swimming the channels: An analysis of online archival reference enquiries [PDF]

open access: yes
Archives of historical and cultural data, such as the UK’s National Archives, receive huge volumes of enquiries from users. These have been seldom systematically studied, despite the obvious benefits to the organisations concerned and interaction ...

core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Equine Assisted Social Work as a mean for authentic relations between clients and staff [PDF]

open access: yes, 2014
The purpose of this study was to explore, by qualitative methods, the meaning of equine-assisted social work (EASW) both to young women with self-harm problems and their staff in residential treatment.
Ranta Nilsson, Daniel   +2 more
core   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy