Results 141 to 150 of about 12,981,608 (292)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Human–Animal Boundary Exploring the Line in Philosophy and Fiction

The Human-Animal Boundary shifts the traditional anthropocentric focus of philosophy and literature by combining the question "what is human?" with the question "what is animal?" The objective is to expand the imaginative scope of human-animal ...
Bjørkdahl, Kristian., Batra, Nandita., Bergamin, Joshua A., Wenning, Mario., Conlan, James P., Comstock, Gary., Grušovnik, Tomaž., Ortiz, Sara Gavrell., Hartigan, John., Mendieta, Eduardo.   +9 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Following the animal : Place, space and literature

, 2018
"Nonhuman animals are ubiquitous to our 'human' societies. Interdisciplinary human/animal research has - for 50 years - drawn attention to how animals are ever-present in what we think of as human spaces and cultures. Our societies are built with animals
Lönngren, Ann-Sofie,
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Human animal interaction, animal assisted therapy and pet ownership in neurorehabilitation

Advances in Clinical Neuroscience & Rehabilitation, 2020
Edwards, Laura
doaj   +1 more source

Editorial: Human-Animal Interaction (HAI) Research: A Decade of Progress. [PDF]

Front Vet Sci, 2020
McCune S, McCardle P, Griffin JA, Esposito L, Hurley K, Bures R, Kruger KA.   +6 more
europepmc   +1 more source

Human Factors in Human-AI Interaction

In the intelligent age, human factors, as a discipline, can effectively help understand and predict the process of human-AI interaction and solve various problems that arise in human-AI interaction.
Sun, Xianghong, Zhang, Jingyu, Zhang, Liang   +2 more
core   +1 more source