Results 131 to 140 of about 13,632,971 (306)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ABSTRACT Understanding and Enhancing

, 2008
There are many interactions that take place at a call centre; between the customer and agent, the agent and computer, and indirectly between the customer and computer.
Call Centre, Computer- Human-human Interaction   +1 more
core  

Towards a semio-cognitive theory of human-computer interaction

, 2001
The research here presented is theoretical and introduces a critical analysis of instrumental approaches in Human-Computer Interaction (HCI). From a semiotic point of view interfaces are not "natural" or "neutral" instruments, but ...
Scolari, Carlos Alberto, 1963-, Carlos A. Scolari   +1 more
core   +1 more source

Understanding glyph characteristics on the legibility for native and non-native speakers in virtual reality

Frontiers in Virtual Reality
IntroductionMultilingual communication shapes education, culture, and decision-making, However, we lack a clear picture of how native writing systems influence visual processing.MethodsWe conducted virtual reality experiments comparing native Chinese ...
Huidan Zhang, Daisuke Sakamoto, Tetsuo Ono   +2 more
doaj   +1 more source

Human-computer interaction as science

Aarhus Series on Human Centered Computing, 2015
<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>The human-computer interaction (HCI) has had a long and troublesome relationship to the role of ‘science’. HCI’s status as an academic object in terms of coherence and adequacy is often in question—leading to desires for establishing a ...
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

INTERACT 2015 Adjunct Proceedings : 15th IFIP TC.13 International Conference on Human-Computer Interaction 14-18 September 2015, Bamberg, Germany [PDF]

, 2015
INTERACT is among the world’s top conferences in Human-Computer Interaction. Starting with the first INTERACT conference in 1990, this conference series has been organised under the aegis of the Technical Committee 13 on Human-Computer Interaction of the
Sutherland, Craig, Farren, Margaret, Darin, Ticianne, Mbaya, Ibrahim R., Holbrook, Jon, Stewart, Michael, Sutherland, Alistar, Wurhofer, Daniela, Luxton-Reilly, Andrew, Feary, Michael, Ghosh, Sanjay, Plimmer, Beryl, Bellino, Alessio, Vasiliou, Christina, Billmann, Dorrit, Toko, Guy, Greis, Miriam, Dermody, Fiona, Swallow, David, Mnkandla, Ernest, Archdeachon, John, Johansson, Stefan, Deshmukh, Rohit   +22 more
core   +1 more source

How AI anxiety and confidence shape student engagement in higher education

Discover Education
The rapid integration of artificial intelligence (AI) into higher education offers opportunities for personalized learning and academic support but may also evoke anxiety, technostress, uncertainty, and concerns about competence, integrity, and future ...
Shakiba Moradi, Pete Evans
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Human Cognition as a Foundation for the Emerging Egocentric Interaction Paradigm

, 2012
This chapter presents an “egocentric interaction paradigm” (EIP) centered on human agents rather than on the notion of user. More specifically, this paradigm is based on perception, action, intention and attention capabilities and limitations of human ...
Surie, Dipak,, Lars-Erik Janlert, Janlert, Lars-Erik,, Dipak Surie, Thomas Pederson, Pederson, Thomas,   +5 more
core   +1 more source