Results 111 to 120 of about 13,632,971 (306)

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Unobtrusive in-situ measurement of behavior change by deep metric similarity learning of motion patterns

open access: yesFrontiers in Virtual Reality
This paper introduces an unobtrusive in-situ measurement method to measure user behavior changes during arbitrary exposures in XR systems. Here, such behavior changes can be elicited by the avatar’s appearance that the users embody.
Christian Merz   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Saliency in human-computer interaction [PDF]

open access: yes, 2006
This paper considers ways in which a person can cue and constrain an artificial agent's attention to salient features. In one experiment, a person uses gestures to direct an otherwise autonomous robot hand through a known task. Each gesture instantiates the key spatial and intentional features for the task at that moment in time.
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Emotive media - A review of emotional interfaces and media in human-computer-interaction

open access: yes, 2016
Emotive Media - thus media environments and interfaces responding and understanding human bio-feedback data can be considered as a new paradigm in the wider field of human-computer-interaction.
Artur Lugmayr (23304919)
core  

HEI! - The Human Environment Interaction

open access: yes, 2007
As computers are becoming more and more ubiquitous, moving from the desktop into the infrastructure of our everyday life, they begin to influence the way we interact with this environment - the (physical) entities that we operate upon in order to achieve
José L. Encarnação   +1 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

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