Results 111 to 120 of about 12,913,201 (303)

Unobtrusive in-situ measurement of behavior change by deep metric similarity learning of motion patterns

Frontiers in Virtual Reality
This paper introduces an unobtrusive in-situ measurement method to measure user behavior changes during arbitrary exposures in XR systems. Here, such behavior changes can be elicited by the avatar’s appearance that the users embody.
Christian Merz, Christian Merz, Lukas Schach, Marie Luisa Fiedler, Marie Luisa Fiedler, Jean-Luc Lugrin, Carolin Wienrich, Marc Erich Latoschik   +7 more
doaj   +1 more source

Dislocated Boardgames: Design Potentials for Remote Tangible Play

Multimodal Technologies and Interaction, 2019
Conventional digital and remote forms of play lack the physicality associated with analog play. Research on the materiality of boardgames has highlighted the inherent material aspects to this analog form of play and how these are relevant for the design ...
Bernhard Maurer, Verena Fuchsberger
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reviewing and extending the five-user assumption: A grounded procedure for interaction evaluation [PDF]

, 2013
" © ACM, 2013. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in ACM Transactions on Computer-Human Interaction (TOCHI), {VOL 20, ISS 5,
Macredie, Robert D., Martin, J, Martin, Jennifer, Borsci, S, Young, Terry, Young, T, Martin, Jennifer L., Macredie, RD, Barnett, J, Barnett, Julie, Kuljis, J, Borsci, Simone, Kuljis, Jasna   +12 more
core   +1 more source

Speed and Accuracy of Gaze Gestures

Journal of Eye Movement Research, 2009
We conducted an experiment where participants carried out six gaze gesture tasks. The gaze paths were analyzed to find out the speed and accuracy of the gaze gestures.
Henna Heikkilä, Kari-Jouko Räihä
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Saliency in human-computer interaction [PDF]

, 2006
This paper considers ways in which a person can cue and constrain an artificial agent's attention to salient features. In one experiment, a person uses gestures to direct an otherwise autonomous robot hand through a known task. Each gesture instantiates the key spatial and intentional features for the task at that moment in time.
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source