Results 111 to 120 of about 720,543 (314)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Habituated interaction and social objects

, 2013
In this position paper we draw from critical approaches to the concept of habit from cultural theory to argue that considering the sociality of everyday objects might be productive for understanding and designing for habituated interaction within the ...
Brereton, Margot, Robertson, T, Nansen, B, Durick, JI, Robertson, Toni, Brereton, M, Durick, J, Vetere, Frank, Vetere, F, Nansen, Bjorn, Durick, Jeannette   +10 more
core  

Learner-Computer Interaction

Learner-Computer Interaction (LCI) research addresses the design, development and use of interactive technologies to support and amplify human learning.
Martinez-Maldonado, Roberto, Giannakos, Michail, Sharma, Kshitij, Dillenbourg, Pierre, Rogers, Yvonne   +4 more
core   +1 more source

Can user choice alter experimental findings in human–computer interaction? : similarity attraction versus cognitive dissonance in social responses to synthetic speech

, 2011
In this study, the effect of the user choice on social responses to computer-synthesized speech is investigated. Three previous findings about social responses to computer-synthesized speech (i.e., social identification, proximate source orientation, and
Jung, Younbo, Nass, Clifford, Kwan Min Lee, Clifford Nass, Younbo Jung, Lee, Kwan Min   +5 more
core   +1 more source

Biologically inspired vision for human-robot interaction [PDF]

, 2018
Human-robot interaction is an interdisciplinary research area that is becoming more and more relevant as robots start to enter our homes, workplaces, schools, etc. In order to navigate safely among us, robots must be able to understand human behavior, to
Farrajota, Miguel, Krishna, Sai, Rodrigues, João M.F., Terzić, Kasim, Saleiro, Mario, du Buf, J. M.Hans   +5 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Human Cognition as a Foundation for the Emerging Egocentric Interaction Paradigm

, 2012
This chapter presents an “egocentric interaction paradigm” (EIP) centered on human agents rather than on the notion of user. More specifically, this paradigm is based on perception, action, intention and attention capabilities and limitations of human ...
Surie, Dipak,, Lars-Erik Janlert, Janlert, Lars-Erik,, Dipak Surie, Thomas Pederson, Pederson, Thomas,   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source