Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
SOCIAL NETWORKING: REASONS TO JOIN AND THINGS DONE BY THE ROMANIAN CONSUMERS - AN EXPLORATORY ASSESSMENT [PDF]
Initially developed in order to allow human interactions in the virtual environment as online communities of people having common concerns and willing to share and exchange ideas, today social networks represent one of the online marketing tools with ...
Pantea Carmen, Veghes Calin
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The importance of being animate: Information selection as a function of dynamic human-environment interactions. [PDF]
Front Psychol, 2022 Bailey RL, Lang A.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
An Ecological Dynamics Approach to Understanding Human-Environment Interactions in the Adventure Sport Context-Implications for Research and Practice. [PDF]
Int J Environ Res Public Health, 2022 Immonen T +3 more
europepmc +1 more source
Global change of land use systems : IMAGE: a new land allocation module [PDF]
The Integrated Model to Assess the Global Environment (IMAGE) aims at assessing the state of the environment taking into account the effects of human activities.
Letourneau, A.P. +2 more
core +1 more source
Investigating context-aware clues to assist navigation for visually impaired people [PDF]
, 2002 It is estimated that 7.4 million people in Europe are visually impaired [1]. Limitations of traditional mobility aids (i.e. white canes and guide dogs) coupled with a proliferation of context-aware technologies (e.g.
Bradley, N.A., Dunlop, M.D.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Correction to 'Late Pleistocene shell midden microstratigraphy indicates a complex history of human-environment interactions in the uplands of North Vietnam'. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 McAdams C +7 more
europepmc +1 more source