Results 201 to 210 of about 19,334 (259)

MolFoundry: A Structure-Aware Generative Framework for De Novo Design of PRRSV Nucleocapsid Candidate Binders. [PDF]

ACS Omega
Hao J, Jin W.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Marine-Derived Sterols from <i>Saccharina japonica</i>: Potential Antibacterial Activity and Target Prediction Against Bacterial Pathogens Through Integrated In Vitro and In Silico Approaches. [PDF]

Pathogens
Lee ES, Kim CM, Song SH, Jeon SB, Kang BS, Ali MS, Lee EB.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Fungal <i>Cordyceps</i> Nucleosides and Analogs as Potential Anti-Glioblastoma PD-L1 Inhibitors: An In Silico Multiparameter Optimization (MPO) Design. [PDF]

Int J Mol Sci
Muñoz-González F, Bello M, Correa-Basurto J, Bandala C.   +3 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

ADME/drug-likeness and functional properties of Punica granatum seeds supported with molecular docking, GC-MS and LC-MS/MS analysis. [PDF]

Sci Rep
Yalçın E, Çavuşoğlu K, Acar A.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Antioxidant Activity, LC-MS/MS Identification and <i>In Silico</i> Analysis of the Ethanol Extract of Beneng Taro Leaves (<i>Xanthosoma undipes</i> K. Koch) Grown in Three Different Locations. [PDF]

Trop Life Sci Res
Widiastuti D, Hariyanto RD, Sinaga SE, Putra WE, Sustiprijatno, Manzila I, Suhendar MA, Triastinurmiatiningsih, Diantina S.   +8 more
europepmc   +1 more source

p-Aminobenzene-Sulfonamide Derivatives of Substituted Pyrimidines as Human Carbonic Anhydrase Inhibitors. [PDF]

Int J Mol Sci
Angeli A, Petrou A, Kartcev V, Prezent M, Sirakanyan S, Geronikaki A, Supuran CT.   +6 more
europepmc   +1 more source