Results 91 to 100 of about 15,477,856 (268)

The effect of rapid social changes during post-communist transition on perceptions of the human - wolf relationships in Macedonia and Kyrgyzstan [PDF]

, 2013
International audienceThe relationship between humans and wolves is often associated with conflicts strongly linked with livestock breeding activities. However, as conflicts are often more intense than expected considering the magnitude of their economic
Lescureux, Nicolas, Linnell, D John C, Nicolas Lescureux, D John C Linnell   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Dialectical Model of Human Nature - Simple

, 2014
The Dialectical Model of Human Nature (DMoHN) explores the interactions between humans and the environment, as a way to understand the nature(s) of cognition and behavior.
Jonathan Cachat (97894)
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Tabula Rasa and Human Nature [PDF]

, 2012
It is widely believed that the philosophical concept of 'tabula rasa' originates with Locke's Essay Concerning Human Understanding and refers to a state in which a child is as formless as a blank slate.
Robert Duschinsky, Duschinsky, Robbie
core   +1 more source

Reimagining Human–Nature Interactions Through the Lens of “Green Education Principles”

Philosophies
The research explores three interconnected themes: philosophy, education, and ecology. It aims to be an interdisciplinary study that emphasizes the significance of the philosophy of environmental education and its practical implications.
Dimitri Jan Jakubowski
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Human–Nature Interaction Pattern Design in Landscape Architecture

Land
Landscape architecture has long engaged esthetics, ecological process, and cultural meaning, and contemporary practice increasingly embraces systemic and process-based approaches. Yet even within this richness, designers often lack systematic tools for addressing how embodied interaction shapes human–nature relationships.
Hongfei Li, Peter H. Kahn
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Biophobia: What it is, how it works and why it matters

People and Nature
Throughout history, humans have maintained an intricate connection with nature, often finding fascination with, and deriving numerous benefits from, the natural world. This positive emotional bond with nature, which is considered to have a genetic basis,
Masashi Soga, Maldwyn J. Evans
doaj   +1 more source