Results 111 to 120 of about 15,477,856 (268)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Perception of Cultural Ecosystem Services by Tourists in Brazilian Protected Areas

Ecology and Evolution
Protected areas play a crucial role in biodiversity conservation, nature tourism, and the provision of ecosystem services, with cultural ecosystem services shaping key human‐nature interactions.
Marcela deFrias Barreto, Rodrigo Lima Massara, Arthur Soares Fernandes, Adriano Pereira Paglia   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Political realism, Freud, and human nature in international relations [PDF]

, 2009
Political realism has enjoyed a renaissance in International Relations (IR). Recent studies have provided insightful accounts of its timeless virtues and philosophical depth.
Schütt, Robert, Schuett, R
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Species and Machines: The Human Subjugation of Nature

, 2017
This book offers a re-examination of the relationship between humans and nature with a new methodology: by examining our entanglement with machines. Using central ideas of critical theory, it uncovers the suppression of nature through technology, tools ...
Hudson, Martyn
core  

Beyond the screen: The psychological significance of ecophilia in childhood

MethodsX
The environmental crisis, fuelled by rapid urbanization, technology, and changing lifestyles, threatens humanity. Children's disconnection from nature negatively impacts their physical, mental, and environmental well-being, increasing their risk of ...
Asha S, Vineeth Radhakrishnan
doaj   +1 more source

Synocene, Beyond the Anthropocene: De-Anthropocentralising Human-Nature-AI Interaction

Extended Abstracts of the CHI Conference on Human Factors in Computing Systems
Recent publications explore AI biases in detecting objects and people in the environment. However, there is no research tackling how AI examines nature. This case study presents a pioneering exploration into the AI attitudes (ecocentric, anthropocentric and antipathetic) toward nature.
Isabelle Hupont, Marina Wainer, Sam Nester, Sylvie Tissot, Lucía Iglesias-Blanco, Sandra Baldassarri   +5 more
openaire   +3 more sources