Results 131 to 140 of about 133,158,617 (301)
Human stomach-on-a-chip with luminal flow and peristaltic-like motility
Lab on a Chip, 2018 Current in vitro approaches and animal models have critical limitations for modeling human gastrointestinal diseases because they may not properly represent multicellular human primary tissues.
Kang Kug Lee +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Retinal organoid chip: engineering a physiomimetic oxygen gradient for optimizing long term culture of human retinal organoids [PDF]
An oxygen gradient across the retina plays a crucial role in its development and function. The inner retina resides in a hypoxic environment (2% O ) adjacent to the vitreous cavity. Oxygenation levels rapidly increase towards the outer retina (18% O ) at
Agarwal, Ashutosh +2 more
core +1 more source
Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro
PLoS ONE, 2017 Analysis of enterovirus infection is difficult in animals because they express different virus receptors than humans, and static cell culture systems do not reproduce the physical complexity of the human intestinal epithelium.
Remi Villenave +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Adaptable Switch boxes as on-chip routing nodes for networks-on-chip [PDF]
, 2005 Eickhoff R, Niemann J-C, Porrmann M, Rückert U. Adaptable Switch boxes as on-chip routing nodes for networks-on-chip. In: Rettberg A, Zanella MC, Rammig FJ, eds. From Specification to Embedded Systems Application .
Eickhoff, Ralf +10 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
From Separation on a Chip to Laboratory on a Chip
, 2008 Lab on a Chip (called ""Microfluidics"") has established itself as an important technology in the area..
林炳承, 秦建华
core
, 2017 This reply to the comment by Nakajima on our article that appeared in Lab on a Chip (E. Amstad, M. Chemama, M. Eggersdorfer, L. R. Arriaga, M. Brenner and D. A.
Amstad, E. +3 more
core +1 more source