Results 111 to 120 of about 133,158,617 (301)

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

Frontiers in Molecular Biosciences, 2020
Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro.
James T. Shoemaker, Wanrui Zhang, Selin I. Atlas, Richard A. Bryan, S. W. Inman, J. Vukašinović   +5 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synchronized Stimulation and Continuous Insulin Sensing in a Microfluidic Human Islet on a Chip Designed for Scalable Manufacturing

Lab on a Chip, 2019
Pancreatic β cell function is compromised in diabetes and is typically assessed by measuring insulin secretion during glucose stimulation. Traditionally, measurement of glucose-stimulated insulin secretion involves manual liquid handling, heterogeneous ...
Aaron L Glieberman, Benjamin D. Pope, J. F. Zimmerman, Qi-Han Liu, John P Ferrier, Jennifer H. R. Kenty, Adrian M. Schrell, Nikita Mukhitov, Kevin L. Shores, A. Tepole, D. Melton, Michael G. Roper, K. K. Parker   +12 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science
The blood–brain barrier (BBB) maintains cerebral homeostasis and protects the central nervous system (CNS) during systemic inflammation. Advanced in vitro models integrating circulation, a functional BBB, and reactive glial cells are essential for ...
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
doaj   +1 more source

Microfluidic Organ-on-a-Chip Models of Human IntestineSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not ...
Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim, Donald E. Ingber   +8 more
doaj   +1 more source

A microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatment

Lab on a Chip, 2019
Human skin models are essential for understanding dermatological diseases and testing new treatment strategies. The use of skin biopsies ex vivo is the most accurate model. However, their use is expensive and exposes the donor to pain and scarring. While
Jae Jung Kim, F. Ellett, C. Thomas, F. Jalali, R. R. Anderson, D. Irimia, A. Raff   +6 more
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Scalability of Network-on-Chip communication architecture for 3-D meshes. [PDF]

, 2009
Design constraints imposed by global interconnect delays as well as limitations in integration of disparate technologies make 3D chip stacks an enticing technology solution for massively integrated electronic systems.
Awet Yemane Weldezion, Tenhunen, Hannu, Matt Grange, Roshan Weerasekera, Grange, M, Jantsch, A, Weldezion, Awet Yemane,, Pamunuwa, Dinesh Bandara, Jantsch, A., Zhonghai Lu, Lu, Zhonghai, Pamunuwa, Dinesh, Dinesh Pamunuwa, Pamunuwa, I D B, Axel Jantsch, Weldezion, A., Weldezion, A. Y., Jantsch, Axel,, Tenhunen, Hannu,, Weerasekera, Roshan, Hannu Tenhunen, Tenhunen, H, Grange, M., Lu, Zhonghai,, Weerasekera, R., Grange, Matt   +25 more
core   +1 more source

Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip

, 2006
Several cell-based biological applications in microfluidic systems require simultaneous high-throughput and individual handling of cells or other bioparticles. Available chip-based tools for contactless manipulation are designed for either high-precision
Jager, M., Lemor, R., Gunther, C., Fuhr, G., Hertz, Hans M.,, Wiklund, Martin,, Wiklund, M., Hertz, H.M.   +7 more
core   +2 more sources