Results 91 to 100 of about 270,658 (298)

Towards Human on a Chip: Recent Progress and Future Perspective

Micro and Nanosystems, 2014
A system of multiple organs integrated on a single chip or human on a chip (HUC) has a great potential for drug discovery. Such a system helps to advance the fundamental understanding of diseases as well as the complex interactions between cells, tissues and organs.
Van Noort, D, Park, S, Nguyen, NT
openaire   +1 more source

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. [PDF]

, 2014
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of
Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hoelting, L., Hogberg, H., Kadereit, S., Kelm, J.M., Landsiedel, R., Leist, M., Lübberstedt, M., McVey, E., Noor, F., Pellevoisin, C., Petersohn, D., Pfannenbecker, U., Ramirez, T., Reisinger, K., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K., Zurich, M.G.   +26 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

EURL ECVAM Workshop on New Generation of Physiologically-Based Kinetic Models in Risk Assessment [PDF]

, 2017
The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Strategy Document on Toxicokinetics (TK) outlines strategies to enable prediction of systemic toxicity by applying new approach methodologies (NAM).
Bessems, J, Desalegn, A, Dorne, JL, Gosling, JP, Heringa, MB, Joossens, E, Klaric, M, Kramer, N, Loizou, G, Louisse, J, Lumen, A, Madden, JC, Paini, A, Patterson, EA, Proenca, S, Punt, A, Setzer, RW, Suciu, N, Tan, YM, Troutman, J, Worth, A, Yoon, M   +21 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology [PDF]

, 2015
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing.
Bouwstra, Joke, Caloni, Francesca, Constant, Samuel, Dandekar, Gudrun, Daneshian, Mardas, Davies, Donna E., Fabian, Eric, Gordon, Sarah, Guzman, Carlos A., Haltner, Eleonore, Hartung, Thomas, Hasiwa, Nina, Hayden, Patrick, Kandarova, Helena, Khare, Sangeeta, Kneuer, Carsten, Krug, Harald F., Lehr, Claus-Michael, Leist, Marcel, Lian, Guoping, Marx, Uwe, Metzger, Marco, Ott, Katharina, Prieto, Pilar, Roberts, Michael S., Roggen, Erwin L., Tralau, Tewes, van den Braak, Claudia, Walles, Heike   +28 more
core   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Monitoring of Electrophysiological Functions in Brain‐on‐a‐Chip and Brain Organoids

Advanced NanoBiomed Research
Though animal models are still the gold standard for fundamental biological studies and drug evaluation for brain diseases, concerns arise from an apparent lack of reflecting the human genetics and pathophysiology.
Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

From mice to clinical relevance: humanizing neuroscience with human-based model systems

Frontiers in Cellular Neuroscience
Preclinical research in neuroscience has traditionally relied on animal models to investigate disease mechanisms and develop new therapeutic strategies.
Aniella Vanessa Bak, Karen M. J. van Loo, Karen M. J. van Loo, Deborah Kronenberg-Versteeg, Deborah Kronenberg-Versteeg, Henner Koch   +5 more
doaj   +1 more source