Results 71 to 80 of about 133,158,617 (301)

Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems

, 2022
S.3963-3978Organ-on-chip (OoC) systems have become a promising tool for personalized medicine and drug development with advantages over conventional animal models and cell assays.
Rogal, Julia, Schneider, S., Weener, H.J., Bubeck, M., Meer, A.D. van der, Loskill, P., Weiss, M., Heymann, M., Rojas, C.   +8 more
core   +1 more source

HIV Biosensors - The Potential of the Electrochemical Way

International Journal of Electrochemical Science, 2014
Because of high costs and time consuming common HIV tests, new ways in diagnosis, offering rapid, cheap, and accuracy possibility are looking for. One of the most promising fields is electrochemistry, providing very good specifity, relatively low price ...
Miguel Angel Merlos Rodrigo, Zbynek Heger, Natalia Cernei, Ana Maria Jimenez Jinemez, Ondrej Zitka, Vojtech Adam, Rene Kizek   +6 more
doaj   +1 more source

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

Frontiers in Bioengineering and Biotechnology, 2020
We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables ...
M. Salman, G. Marsh, Ilja Kusters, Matthieu Delincé, G. Di Caprio, S. Upadhyayula, G. de Nola, Ronan Hunt, Kazuka G. Ohashi, Taylor Gray, Fumitaka Shimizu, Yasuteru Sano, T. Kanda, B. Obermeier, T. Kirchhausen   +14 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identification of urban particulate matter-induced disruption of human respiratory mucosa integrity using whole transcriptome analysis and organ-on-a chip

Journal of Biological Engineering, 2019
Background Exposure to air particulate matter (PM) is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have been performed in cell culture using a single cell type.
Junhyoung Byun, Boa Song, Kyungwoo Lee, Byoungjae Kim, Hae Won Hwang, Myung-Ryul Ok, Hojeong Jeon, Kijeong Lee, Seung-Kuk Baek, Sang-Heon Kim, Seung Ja Oh, Tae Hoon Kim   +11 more
doaj   +1 more source

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Advanced Functional Materials
The coordinated migration of invasive tumor cells is a complex and dynamic mechanism driven by diverse cellular and molecular events. Unfortunately, the inherent heterogeneity within tumors raises multiple challenges in deciphering key biomarkers and ...
Cátia F. Monteiro, I. Deus, I. Silva, I. Duarte, C. A. Custódio, J. Mano   +5 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

, 2018
Liver organoids derived from human pluripotent stem cells (PSCs) represent a new type of in vitro liver model for understanding organ development, disease mechanism and drug testing.
Qin, Jianhua, Wang, Yaqing, Wang, Hui, Guo, Yaqiong, Deng, Pengwei, Chen, Wenwen, Tao, Tingting   +6 more
core   +1 more source

Tecnologia organ-on-a chip: verificação do cenário global da aplicabilidade no contexto regulatório de produtos farmacêuticos

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia
Introdução: Os métodos tradicionais dos estudos pré-clínicos com animais podem não refletir com precisão a eficácia e a segurança de um composto em seres humanos.
Núbia Regina de Oliveira, Wanise Borges Gouveia Barroso, Isabella Fernandes Delgado   +2 more
doaj   +1 more source

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction The quest to identify an effective therapeutic strategy for neurodegenerative diseases, such as mild congitive impairment (MCI) and Alzheimer's disease (AD), suffers from the lack of good human‐based models. Animals represent the most common
Julbert Caneus, Nesar Akanda, John W. Rumsey, Xiufang Guo, Max Jackson, Christopher J. Long, Frank Sommerhage, Sanya Georgieva, Nicholas M. Kanaan, David Morgan, James J. Hickman   +10 more
doaj   +1 more source