Results 1 to 10 of about 195,163 (139)

A Real-Time Sensing System for Monitoring Neural Network Degeneration in an Alzheimer's Disease-on-a-Chip Model. [PDF]

Pharmaceutics, 2022
Stem cell-based in vitro models may provide potential therapeutic strategies and allow drug screening for neurodegenerative diseases, including Alzheimer’s disease (AD). Herein, we develop a neural stem cell (NSC) spheroid-based biochip that is characterized by a brain-like structure, well-defined neural differentiation, and neural network formation ...
Liu NC, Liang CC, Li YE, Lee IC.
europepmc   +4 more sources

Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells. [PDF]

Sci Rep, 2020
AbstractDisease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic and their response to an applied stress is highly dependent on the magnitude and ...
Armistead FJ, Gala De Pablo J, Gadêlha H, Peyman SA, Evans SD.   +4 more
europepmc   +8 more sources

Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models. [PDF]

J Hazard Mater
Micro and nanoplastics (MNPs) are widespread environmental and food web contaminants that are absorbed by the intestine and distributed systemically, but the mechanisms of uptake are not well understood. In a triculture small intestinal epithelial model, we previously found that uptake of 26 nm polystyrene MNPs (PS26) occurred by both passive diffusion
Kharaghani D, DeLoid GM, He P, Swenor B, Bui TH, Zuverza-Mena N, Tamez C, Musante C, Verzi M, White JC, Demokritou P.   +10 more
europepmc   +3 more sources

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

Biosensors, 2022
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering to replicate the critical physiological environment and functions of the human organs.
Zening Li, Jianan Hui, Panhui Yang, Hongju Mao   +3 more
doaj   +3 more sources

Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease”

Advanced Science, 2022
Diabetes mellitus (DM) is closely related to Alzheimer's disease (AD), but individual cellular changes and the possibilities of recovery through molecular level regulation have not been investigated.
Minjeong Jang, Nakwon Choi, Hong Nam Kim
doaj   +2 more sources

Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model. [PDF]

Mater Today Bio
Gold nanoparticles (GNP) are highly valuable in nanotechnology due to their biocompatibility and unique physicochemical properties, which make them attractive as nanocarriers for targeted drug delivery. In the context of neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), GNP hold promise for reducing the toxicity of Amyloid-β peptide ...
Arellano A, Palma-Florez S, Cabrera P, Cortés-Adasme E, Bolaños K, Celis F, Araya-Vergara AJ, Pérez M, Crespo A, Matus MH, Araya E, Aldunate R, Kogan MJ, Samitier J, Lagunas A, Mir M, Hassan N.   +16 more
europepmc   +4 more sources

Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform. [PDF]

Front Cardiovasc Med
Background Early-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL). Worldwide studies have revealed that aortic valve disease accounts for up to 43%
Mendoza-Seale M, Chen MH, Huang P, Mahler GJ.   +3 more
europepmc   +3 more sources

Editorial: Disease-on-a-chip: from point-of-care to personalized medicine. [PDF]

Front Pharmacol, 2023
Cruz A, Fernandes E, Rodrigues RO, Catarino SO, Pinho D.   +4 more
europepmc   +4 more sources

Gut-on-a-chip for disease models

Journal of Tissue Engineering, 2023
The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be ...
Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li   +3 more
doaj   +2 more sources

Vasculature-On-A-Chip for In Vitro Disease Models

Bioengineering, 2017
Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial ...
Seunggyu Kim, Wanho Kim, Seongjin Lim, Jessie S. Jeon   +3 more
doaj   +3 more sources