Results 1 to 10 of about 204,111 (283)

Disease-on-a-chip: mimicry of tumor growth in mammary ducts. [PDF]

Lab Chip, 2014
We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts.
Vidi PA, Maleki T, Ochoa M, Wang L, Clark SM, Leary JF, Lelièvre SA.   +6 more
europepmc   +6 more sources

A Real-Time Sensing System for Monitoring Neural Network Degeneration in an Alzheimer's Disease-on-a-Chip Model. [PDF]

Pharmaceutics, 2022
Stem cell-based in vitro models may provide potential therapeutic strategies and allow drug screening for neurodegenerative diseases, including Alzheimer’s disease (AD). Herein, we develop a neural stem cell (NSC) spheroid-based biochip that is characterized by a brain-like structure, well-defined neural differentiation, and neural network formation ...
Liu NC, Liang CC, Li YE, Lee IC.
europepmc   +4 more sources

Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells. [PDF]

Sci Rep, 2020
AbstractDisease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic and their response to an applied stress is highly dependent on the magnitude and ...
Armistead FJ, Gala De Pablo J, Gadêlha H, Peyman SA, Evans SD.   +4 more
europepmc   +9 more sources

Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models. [PDF]

J Hazard Mater
Micro and nanoplastics (MNPs) are widespread environmental and food web contaminants that are absorbed by the intestine and distributed systemically, but the mechanisms of uptake are not well understood. In a triculture small intestinal epithelial model, we previously found that uptake of 26 nm polystyrene MNPs (PS26) occurred by both passive diffusion
Kharaghani D, DeLoid GM, He P, Swenor B, Bui TH, Zuverza-Mena N, Tamez C, Musante C, Verzi M, White JC, Demokritou P.   +10 more
europepmc   +3 more sources

Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform. [PDF]

Front Cardiovasc Med
Background Early-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL). Worldwide studies have revealed that aortic valve disease accounts for up to 43%
Mendoza-Seale M, Chen MH, Huang P, Mahler GJ.   +3 more
europepmc   +3 more sources

Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model. [PDF]

Mater Today Bio
Gold nanoparticles (GNP) are highly valuable in nanotechnology due to their biocompatibility and unique physicochemical properties, which make them attractive as nanocarriers for targeted drug delivery. In the context of neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), GNP hold promise for reducing the toxicity of Amyloid-β peptide ...
Arellano A, Palma-Florez S, Cabrera P, Cortés-Adasme E, Bolaños K, Celis F, Araya-Vergara AJ, Pérez M, Crespo A, Matus MH, Araya E, Aldunate R, Kogan MJ, Samitier J, Lagunas A, Mir M, Hassan N.   +16 more
europepmc   +4 more sources

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

Biosensors, 2022
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering to replicate the critical physiological environment and functions of the human organs.
Zening Li, Jianan Hui, Panhui Yang, Hongju Mao   +3 more
doaj   +3 more sources

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

International Journal of Molecular Sciences, 2019
A common bottleneck in any drug development process is finding sufficiently accurate models that capture key aspects of disease development and progression.
Claudia Beaurivage, Arnaud Nicolas, Paul Vulto   +2 more
exaly   +2 more sources

Editorial: Disease-on-a-chip: from point-of-care to personalized medicine. [PDF]

Front Pharmacol, 2023
Cruz A, Fernandes E, Rodrigues RO, Catarino SO, Pinho D.   +4 more
europepmc   +4 more sources

Lab on a Chip Device for Diagnostic Evaluation and Management in Chronic Renal Disease: A Change Promoting Approach in the Patients’ Follow Up

Biosensors, 2023
Lab-on-a-chip (LOC) systems are miniaturized devices aimed to perform one or several analyses, normally carried out in a laboratory setting, on a single chip. LOC systems have a wide application range, including diagnosis and clinical biochemistry.
Margherita Borriello, Giuseppe Tarabella, Pasquale D’Angelo, Aris Liboà, Mario Barra, Davide Vurro, Patrizia Lombari, Annapaola Coppola, Elvira Mazzella, Alessandra F. Perna, Diego Ingrosso   +10 more
doaj   +3 more sources