Results 41 to 50 of about 204,111 (283)
Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip
Nano Convergence, 2022 The intestinal microbiome affects a number of biological functions of the organism. Although the animal model is a powerful tool to study the relationship between the host and microbe, a physiologically relevant in vitro human intestinal system has still
Min Seo Jeon +9 more
doaj +1 more source
Frontiers in Bioengineering and BiotechnologyOrganoids are stem-cell derived tissue structures mimicking specific structural and functional characteristics of human organs. Despite significant advancements in the field over the last decade, challenges like limited long-term functional culture and ...
L. Papamichail +4 more
semanticscholar +1 more source
A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications
BiosensorsOrgan-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost +1 more
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Intestine‐on‐a‐chip for intestinal disease study and pharmacological research
View, 2023 Intestinal diseases seriously affect the quality of life. The assays for intestinal disease study based on two‐dimensional in vitro cell culture and animal models fail to model human physiology and pathophysiology accurately. As a bridge between in vitro
Dongxue Zhang, Liang Qiao
doaj +1 more source
Cell Reports, 2018 Huntington's disease (HD), a devastating neurodegenerative disorder, strongly affects the corticostriatal network, but the contribution of pre- and postsynaptic neurons in the first phases of disease is unclear due to difficulties performing early ...
A. Virlogeux +8 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei +17 more
wiley +1 more source
Heart-on-a-chip systems: disease modeling and drug screening applications.
Lab on a ChipCardiovascular disease (CVD) is the leading cause of death worldwide, casting a substantial economic footprint and burdening the global healthcare system.
Derrick Butler, Darwin R. Reyes
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body‐altering treatment. This cross‐sectional study aimed to evaluate generic and survivor‐specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and ...
Hinke van der Hoek +14 more
wiley +1 more source
A novel vascularized urethra-on-a-chip model
Scientific ReportsThe male urethra transports urine and semen. Any disease of the male urethra, hindering normal voiding or ejaculation, has a major impact on quality of life. Urethral stricture disease is common and molecular research into urethral strictures is hampered
Aina Casademont-Roca +5 more
doaj +1 more source