Results 21 to 30 of about 204,111 (283)

Corrigendum to "Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models" [J Hazard Mater 490 (2025) 137714]. [PDF]

J Hazard Mater
Kharaghani D, DeLoid GM, He P, Swenor B, Bui TH, Zuverza-Mena N, Tamez C, Musante C, Verzi M, White JC, Demokritou P.   +10 more
europepmc   +2 more sources

Human Motor System‐Based Biohybrid Robot‐On‐a‐Chip for Drug Evaluation of Neurodegenerative Disease

Advancement of science, 2023
Biohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system.
Minkyu Shin, Taehyeong Ha, Joungpyo Lim, Joohyun An, Geunyoung Beak, Jin‐Ha Choi, A. Melvin, Jinho Yoon, Jeong-Woo Choi   +8 more
semanticscholar   +1 more source

Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease

Biofabrication, 2023
Exploring the pathogenesis of and developing therapies for cholestatic liver diseases such as primary sclerosing cholangitis (PSC) remains challenging, partly due to a paucity of in vitro models that capture the complex environments contributing to ...
Yu Du, I. D. de Jong, Kapish Gupta, O. Waisbourd-Zinman, Adi Har-Zahav, C. Soroka, J. Boyer, J. Llewellyn, Chengyang Liu, A. Naji, William Polacheck, R. G. Wells   +11 more
semanticscholar   +1 more source

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease

bioRxiv, 2022
Background The lack of predictive models that mimic the blood–brain barrier (BBB) hinders the development of effective drugs for neurodegenerative diseases. Animal models behave differently from humans, are expensive and have ethical constraints.
Sujey Palma-Florez, Adrián López-Canosa, Francisco Moralez-Zavala, Ó. Castaño, M. Kogan, J. Samitier, A. Lagunas, M. Mir   +7 more
semanticscholar   +1 more source

Opportunities and considerations for studying liver disease with microphysiological systems on a chip

Lab on a Chip, 2023
Advances in microsystem engineering have enabled the development of highly controlled models of the liver that better recapitulate the unique in vivo biological conditions. In just a few short years, substantial progress has been made in creating complex
Adiya Otumala, Dominick J. Hellen, C. A. Luna, P. Delgado, A. Dissanayaka, C. Ugwumadu, O. Oshinowo, Md. Mydul Islam, Luyao Shen, S. Karpen, D. Myers   +10 more
semanticscholar   +1 more source

Cytokine induced inflammatory bowel disease model using organ-on-a-chip technology

PLoS ONE, 2023
Over 2 million people in North America suffer from inflammatory bowel disease (IBD), a chronic and idiopathic inflammatory condition. While previous research has primarily focused on studying immune cells as a cause and therapeutic target for IBD, recent
Christine A. Tataru, Maya Livni, Carrie L. Marean-Reardon, M. C. Franco, M. David   +4 more
semanticscholar   +1 more source

Mobile Efficient Diagnostics of Infectious Diseases via On‐Chip RT‐qPCR: MEDIC‐PCR

Advanced Science, 2023
AbstractThe COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control.
Kiran Shrestha, Seongryeong Kim, Jiyeon Han, Gabriela Morales Florez, Han Truong, Trung Hoang, Sajjan Parajuli, Tiara AM, Beomsoo Kim, Younsu Jung, Abdurhaman Teyib Abafogi, Yugyeong Lee, Seung Hyun Song, Jinkee Lee, Sungsu Park, Minhee Kang, Hee Jae Huh, Gyoujin Cho, Luke P. Lee   +18 more
openaire   +3 more sources

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model.

Neurobiology of Disease, 2022
Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (BDNF).
Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, C. Scaramuzzino, A. Virlogeux, Laetitia Capellano, A. Genoux, Noga Gershoni-Emek, M. Geva, M. R. Hayden, F. Saudou   +10 more
semanticscholar   +1 more source

Development of oxidative stress-associated disease models using feto-maternal interface organ-on-a-chip

The FASEB Journal, 2023
Oxidative stress (OS) and inflammation arising from cellular derangements at the fetal membrane‐decidual interface (feto‐maternal interface [FMi]) is a major antecedent to preterm birth (PTB). However, it is impractical to study OS‐associated FMi disease
Lauren S. Richardson, A. Kammala, Sungjin Kim, Po Yi Lam, Nina Truong, E. Radnaa, Rheanna Urrabaz‐Garza, Arum Han, R. Menon   +8 more
semanticscholar   +1 more source

Construction of diagnostic markers for hub lncRNAs in Parkinson’s disease based on chip re-annotation [PDF]

, 2021
Abstract BACKGROUND Parkinson’s disease (PD) is a progressive neurodegenerative disease that is also the most common motor disorder and is accompanied by the loss of DA neurons in the brain. Long non-coding RNAs (lncRNAs) have recently been identified as new genetic entities that regulate cellular processes.
Yi Quan, Shuo Wang, Jia Wang, Jizong Zhao   +3 more
openaire   +1 more source