Results 21 to 30 of about 195,333 (281)
Disease-on-a-chip: mimicry of tumor growth in mammary ducts [PDF]
Lab Chip, 2014 We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces.
Vidi, Pierre-Alexandre +6 more
openaire +3 more sources
Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj +1 more source
Alveolus Lung-on-a-Chip Platform: A Proposal
Chemosensors, 2021 Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments ...
Noelia Campillo +2 more
doaj +1 more source
Mobile Efficient Diagnostics of Infectious Diseases via On‐Chip RT‐qPCR: MEDIC‐PCR
Advanced Science, 2023 AbstractThe COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control.
Kiran Shrestha +18 more
openaire +3 more sources
Construction of diagnostic markers for hub lncRNAs in Parkinson’s disease based on chip re-annotation [PDF]
, 2021 Abstract BACKGROUND Parkinson’s disease (PD) is a progressive neurodegenerative disease that is also the most common motor disorder and is accompanied by the loss of DA neurons in the brain. Long non-coding RNAs (lncRNAs) have recently been identified as new genetic entities that regulate cellular processes.
Yi Quan +3 more
openaire +1 more source
Entwicklung und Automatisierung 3D-gedruckter mikrofluidischer Systeme zur Integration und Kultivierung adhärenter Zellkulturen [PDF]
, 2022 Mikrofluidische Systeme werden zur Manipulation von Flüssigkeiten auf Mikroebene eingesetzt. Von ihnen profitieren insbesondere Biowissenschaften durch die Reduktion von Reagenzien und die Automatisierung ganzer Arbeitsabläufe.
Winkler, Steffen Nils
core +1 more source
Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends [PDF]
, 2022 Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research.
Carvalho, M. R. +14 more
core +1 more source
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
The solitary nucleus connectivity to key autonomic regions in humans [PDF]
, 2022 The nucleus tractus solitarius (NTS) is a key brainstem structure relaying interoceptive peripheral information to the interrelated brain centres for eliciting rapid autonomic responses and for shaping longer-term neuroendocrine and motor patterns ...
Baron, Ralf +6 more
core +1 more source
Bioactive Materials, 2022 All-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable hydrogels.
Hyo-Jin Yoon +17 more
openaire +4 more sources