Results 1 to 10 of about 270,177 (153)

A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics [PDF]

Frontiers in Cell and Developmental Biology, 2021
Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness ...
Virginia M. Smith, Virginia M. Smith, Huan Nguyen, John W. Rumsey, Christopher J. Long, Michael L. Shuler, James J. Hickman, James J. Hickman   +7 more
doaj   +2 more sources

Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions. [PDF]

Micromachines (Basel), 2021
For centuries, animal experiments have contributed much to our understanding of mechanisms of human disease, but their value in predicting the effectiveness of drug treatments in the clinic has remained controversial. Animal models, including genetically modified ones and experimentally induced pathologies, often do not accurately reflect disease in ...
Pun S, Haney LC, Barrile R.
europepmc   +5 more sources

The ethical aspects of human organ-on-chip models: A mapping review. [PDF]

Stem Cell Reports
Organ-on-chips (OoCs) are controlled microfluidic platforms that replicate specific organ-level functionalities and pathological processes using cultured cells. OoCs promise to enhance drug discovery, reduce dependence on animal models, and enable personalized treatments. However, OoCs also introduce ethical challenges.
Weidema J, de Vries M, Mummery C, de Graeff N.   +3 more
europepmc   +3 more sources

Investigations on T cell transmigration in a human skin-on-chip (SoC) model. [PDF]

Lab Chip, 2021
Our skin-on-chip (SoC) model uniquely enabled quantitative studies of transendothelial and transepithelial migration of human T lymphocytes under mimicked inflammatory skin conditions and was used to test new drug candidates.
Ren X, Getschman AE, Hwang S, Volkman BF, Klonisch T, Levin D, Zhao M, Santos S, Liu S, Cheng J, Lin F.   +10 more
europepmc   +5 more sources

A human-on-a-chip approach to tackling rare diseases. [PDF]

Drug Discov Today, 2019
Drug development for rare diseases, classified as diseases with a prevalence of < 200 000 patients, is limited by the high cost of research and low target population. Owing to a lack of representative disease models, research has been challenging for orphan drugs.
de Mello CPP, Rumsey J, Slaughter V, Hickman JJ.   +3 more
europepmc   +4 more sources

Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies. [PDF]

Adv Ther (Weinh), 2022
AbstractChronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune demyelinating neuropathies, chronic inflammatory demyelinating polyneuropathy (CIDP) and ...
Rumsey JW, Lorance C, Jackson M, Sasserath T, McAleer CW, Long CJ, Goswami A, Russo MA, Raja SM, Gable KL, Emmett D, Hobson-Webb LD, Chopra M, Howard JF, Guptill JT, Storek MJ, Alonso-Alonso M, Atassi N, Panicker S, Parry G, Hammond T, Hickman JJ.   +21 more
europepmc   +3 more sources

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip. [PDF]

Sci Bull (Beijing), 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. Clinical evidence suggests that the intestine is another high-risk organ for SARS-CoV-2 infection besides the lungs.
Guo Y, Luo R, Wang Y, Deng P, Song T, Zhang M, Wang P, Zhang X, Cui K, Tao T, Li Z, Chen W, Zheng Y, Qin J.   +13 more
europepmc   +3 more sources

Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform. [PDF]

Adv Sci (Weinh)
AbstractGalactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective measures against space travel exposures.
Tavakol DN, Nash TR, Kim Y, Graney PL, Liberman M, Fleischer S, Lock RI, O'Donnell A, Andrews L, Ning D, Yeager K, Harken A, Deoli N, Amundson SA, Garty G, Leong KW, Brenner DJ, Vunjak-Novakovic G.   +17 more
europepmc   +4 more sources

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction The quest to identify an effective therapeutic strategy for neurodegenerative diseases, such as mild congitive impairment (MCI) and Alzheimer's disease (AD), suffers from the lack of good human‐based models. Animals represent the most common
Julbert Caneus, Nesar Akanda, John W. Rumsey, Xiufang Guo, Max Jackson, Christopher J. Long, Frank Sommerhage, Sanya Georgieva, Nicholas M. Kanaan, David Morgan, James J. Hickman   +10 more
doaj   +2 more sources

Multi-Sensors Integration in a Human Gut-On-Chip Platform [PDF]

Proceedings, 2018
In the conventional culture systems in vitro, the challenging organoid approach have recently been overcome by the development of microfluidic Organ Chip models of human intestine.
Lucia Giampetruzzi, Amilcare Barca, Flavio Casino, Simonetta Capone, Tiziano Verri, Pietro Siciliano, Luca Francioso   +6 more
doaj   +5 more sources