Results 1 to 10 of about 274,314 (115)

A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics [PDF]

Frontiers in Cell and Developmental Biology, 2021
Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness ...
Virginia M. Smith, Virginia M. Smith, Huan Nguyen, John W. Rumsey, Christopher J. Long, Michael L. Shuler, James J. Hickman, James J. Hickman   +7 more
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A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction The quest to identify an effective therapeutic strategy for neurodegenerative diseases, such as mild congitive impairment (MCI) and Alzheimer's disease (AD), suffers from the lack of good human‐based models. Animals represent the most common
Julbert Caneus, Nesar Akanda, John W. Rumsey, Xiufang Guo, Max Jackson, Christopher J. Long, Frank Sommerhage, Sanya Georgieva, Nicholas M. Kanaan, David Morgan, James J. Hickman   +10 more
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Sistemas microfisiológicos compostos por organoides humanos em dispositivos microfluídicos: avanços e desafios

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj   +7 more sources

Microfluidic Gut-on-a-Chip: Fundamentals and Challenges

Biosensors, 2023
The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta   +3 more
doaj   +1 more source

Organ-On-A-Chip: An Emerging Research Platform

Organogenesis, 2023
In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology.
Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya, Shaila Lewis   +4 more
doaj   +1 more source

A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin

Frontiers in Toxicology, 2022
Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of oral mucosa to metals, which are known to activate the immune system and in turn may result in ...
Jasper J. Koning, Charlotte T. Rodrigues Neves, Katharina Schimek, Maria Thon, Sander W. Spiekstra, Taco Waaijman, Tanja D. de Gruijl, Susan Gibbs, Susan Gibbs   +8 more
doaj   +1 more source

Human Nonalcoholic Steatohepatitis on a Chip

Hepatology Communications, 2021
Nonalcoholic steatohepatitis (NASH), an advanced stage of nonalcoholic fatty liver disease (NAFLD), is a rapidly growing and global health problem compounded by the current absence of specific treatments. A major limiting factor in the development of new
May S. Freag, Bumseok Namgung, Maria E. Reyna Fernandez, Ermanno Gherardi, Shiladitya Sengupta, Hae Lin Jang   +5 more
doaj   +1 more source

Cylindrical core-shell tween 80 micelle templated green synthesis of gold-silver hollow cubic nanostructures as efficient nanocatalysts

Materials & Design, 2018
The non-ionic surfactant, Tween 80 (T80) a material with promising applications in the pharmaceutical, cosmetic, and food industries, has been explored here for the design of novel nanostructures (NS).
Dickson Joseph, Hoomin Lee, Yun Suk Huh, Young-Kyu Han   +3 more
doaj   +1 more source

Organ-on-a-chip: recent breakthroughs and future prospects

BioMedical Engineering OnLine, 2020
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip.
Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen, Xiuqing Gong   +7 more
doaj   +1 more source

Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip

Frontiers in Cell and Developmental Biology, 2022
Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology.
Bolin Jing, Bolin Jing, Kun Xia, Chen Zhang, Siming Jiao, Limeng Zhu, Jinhua Wei, Zhuo A. Wang, Nannan Chen, Pengfei Tu, Jianjun Li, Yuguang Du   +11 more
doaj   +1 more source