Results 1 to 10 of about 133,158,617 (301)

Standard: human liver-on-a-chip

Cell Regeneration
Organs-on-chips are microphysiological systems designed to replicate key functions of human organs, thereby accelerating innovation in life sciences, such as disease modeling, drug development, and precision medicine.
Haitao Liu, Xu Zhang, Yaqing Wang, Min Zhang, Peng Wang, Jing Shang, Zhongqiang Li, Likun Gong, Xin Xie, Dongyang Liu, Jingbo Pi, Xinghua Gao, Xianliang Li, Wei Ding, Dianbing Wang, Yun Long, Lan Wang, Song Li, Xingchao Geng, Pingkun Zhou, Wanjin Tang, Xian’en Zhang, Chunying Chen, Shengli Yang, Jianhua Qin   +24 more
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Towards Multi-Organoid Systems for Drug Screening Applications

Bioengineering, 2018
A low percentage of novel drug candidates succeed and reach the end of the drug discovery pipeline, mainly due to poor initial screening and assessment of the effects of the drug and its metabolites over various tissues in the human body.
Cláudia C. Miranda, Tiago G. Fernandes, Maria Margarida Diogo, Joaquim M. S. Cabral   +3 more
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Standard: human intestine-on-a-chip

Cell Regeneration
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate the innovation in life sciences including disease modeling, drug development, and precision medicine.
Haitao Liu, Yaqing Wang, Xu Zhang, Min Zhang, Peng Wang, Jing Shang, Zhongqiang Li, Likun Gong, Jiabin Guo, Wei Sun, Jingbo Pi, Xianliang Li, Wei Ding, Dianbing Wang, Zhongyu Li, Jingzhong Zhang, Lan Wang, Xingchao Geng, Ruifu Yang, Pingkun Zhou, Wanjin Tang, Xian’en Zhang, Chunying Chen, Shengli Yang, Jianhua Qin   +24 more
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Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function

Cell Reports: Methods
Summary: An in vitro model of human liver with functional integrity would advance liver research and enable personalized therapeutics. A microfluidic liver-on-a-chip can generate a functional hepatobiliary network using human liver cells and recapitulate
Anastasia Brooks, Haotian Yang, Deborah S. Barkauskas, Supun Ranaweera, Da Zou, Sally Goh, Qi Ruan, Kim Bridle, Darrell H.G. Crawford, Xin Liu, Michael S. Roberts, Michael R. Doran, Xiaowen Liang, Chun-Xia Zhao, Haolu Wang   +14 more
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Assessment of nanotoxicity in a human placenta-on-a-chip from trophoblast stem cells

Ecotoxicology and Environmental Safety
Maternal exposure to nanoparticles during gestation poses potential risks to fetal development. The placenta, serving as a vital interface for maternal-fetal interaction, plays a pivotal role in shielding the fetus from direct nanoparticle exposure ...
Rongkai Cao, Yuxin Guo, Jiayue Liu, Yaqiong Guo, Xiang Li, Fuwei Xie, Yaqing Wang, Jianhua Qin   +7 more
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Human breast tissue engineering in health and disease

EMBO Molecular Medicine
The human mammary gland represents a highly organized and dynamic tissue, uniquely characterized by postnatal developmental cycles. During pregnancy and lactation, it undergoes extensive hormone-stimulated architectural remodeling, culminating in the ...
Maj-Britt Buchholz, Demi I Scheerman, Riccardo Levato, Ellen J Wehrens, Anne C Rios   +4 more
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Three-Dimensional Human Skin Models for Translational Dermatology: Current Platforms, Applications, and Open Questions

International Journal of Translational Medicine
Human skin remains difficult to model in vitro because it brings together stratified epidermal, dermal, hypodermal, vascular, immune, appendageal, neural, and microbial elements within a single tissue.
Jennifer Toral-Orduno, Rohit D. Reddy, Nabiha Yusuf   +2 more
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Validation of a functional human AD model with four AD therapeutics utilizing patterned ipsc-derived cortical neurons integrated with microelectrode arrays

Scientific Reports
Preclinical methods are needed for screening potential Alzheimer’s disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease.
Julbert Caneus, Kaveena Autar, Nesar Akanda, Marcella Grillo, Christopher J. Long, Max Jackson, Sarah Lindquist, Xiufang Guo, Dave Morgan, James J. Hickman   +9 more
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A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science
We developed a human Bone‐on‐a‐Chip (BOAC) model that integrates autologous primary immune and bone cells on native human bone substrates within a xeno‐free, perfused environment.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
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Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid

Regenerative Therapy
Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow.
Abhiraj Kesharwani, Shoichiro Tani, Masaki Nishikawa, Yasuyuki Sakai, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Hironori Hojo   +7 more
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