Results 31 to 40 of about 274,463 (252)

Revolutionizing nephrology research: expanding horizons with kidney-on-a-chip and beyond

Frontiers in Bioengineering and Biotechnology
Organs-on-a-chip (OoC) is a microengineered three-dimensional cell culture system developed for decades. Utilizing microfluidic technology, OoC cultivates cells on perfusable channels to construct in vitro organ models, enabling the simulation of organ ...
Wei Huang, Yi-Yuan Chen, Fang-Fang He, Chun Zhang   +3 more
doaj   +1 more source

The method to generate pulsatile circulatory fluid flow using microfluidics

MethodsX, 2021
Microfluidic chips provide versatile tools to mimic the biological effect of blood flow on pluripotent stem cells (PSC). This paper presents methods for the use of microfluidics to model embryonic circulation using differentiated PSC.
Jingjing Li, Osmond Lao, Robert E. Nordon   +2 more
doaj   +1 more source

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost, Soumya K. Srivastava   +1 more
doaj   +1 more source

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Microorganisms, 2020
Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense. In this study, we analyzed whether
Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S. Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer   +17 more
doaj   +1 more source

Towards establishing human body-on-a-chip systems

Stem Cell Research & Therapy, 2022
Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj   +1 more source

Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. [PDF]

Adv Funct Mater, 2019
AbstractThe goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the human response to compounds within physiologically relevant platforms. The generation and characterization of such systems is currently a focal point of research given the long‐standing inadequacies of conventional techniques for predicting human outcome ...
Oleaga C, Lavado A, Riu A, Rothemund S, Carmona-Moran CA, Persaud K, Yurko A, Lear J, Narasimhan NS, Long CJ, Sommerhage F, Bridges LR, Cai Y, Martin C, Schnepper MT, Goswami A, Note R, Langer J, Teissier S, Cotovio J, Hickman JJ.   +20 more
europepmc   +3 more sources

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

Biochemical Journal, 2023
The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing ...
openaire   +2 more sources

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

Frontiers in Bioengineering and Biotechnology, 2020
Microengineered systems provide an in vitro strategy to explore the variability of individual patient response to tissue engineering products, since they prefer the use of primary cell sources representing the phenotype variability.
Gabriele Nasello, Gabriele Nasello, Pilar Alamán-Díez, Jessica Schiavi, María Ángeles Pérez, Laoise McNamara, José Manuel García-Aznar   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source