Results 31 to 40 of about 270,658 (298)

Organic Anion Transporting Polypeptide 2B1 in Human Fetal Membranes: A Novel Gatekeeper for Drug Transport During Pregnancy?

open access: yesFrontiers in Pharmacology, 2021
Current intervention strategies have not been successful in reducing the risks of adverse pregnancy complications nor maternal and fetal morbidities associated with pregnancy complications.
Esha Ganguly   +6 more
doaj   +1 more source

Developmentally inspired human ‘organs on chips’ [PDF]

open access: yesDevelopment, 2018
ABSTRACT Although initially developed to replace animal testing in drug development, human ‘organ on a chip’ (organ chip) microfluidic culture technology offers a new tool for studying tissue development and pathophysiology, which has brought us one step closer to carrying out human experimentation in vitro.
openaire   +2 more sources

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture [PDF]

open access: yes, 2013
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Brincker, Sven   +11 more
core   +2 more sources

Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies

open access: yesMarine Drugs, 2018
Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous ...
Vivek K. Bajpai   +6 more
doaj   +1 more source

Fluorescent optical fiber sensors for cell viability monitoring [PDF]

open access: yes, 2013
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Marx, Uwe   +5 more
core   +1 more source

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development [PDF]

open access: yes, 2014
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations.
Borenstein, Jeffrey T.   +4 more
core   +1 more source

Cystic Fibrosis Human Organs-on-a-Chip

open access: yesMicromachines, 2021
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most ...
Herbert Luke Ogden   +4 more
doaj   +1 more source

On being the right size: scaling effects in designing a human-on-a-chip [PDF]

open access: yesIntegrative Biology, 2013
Developing a human-on-a-chip by connecting multiple model organ systems would provide an intermediate screen for therapeutic efficacy and toxic side effects of drugs prior to conducting expensive clinical trials. However, correctly designing individual organs and scaling them relative to each other to make a functional microscale human analog is ...
Moraes, Christopher   +5 more
openaire   +3 more sources

Human organs-on-chips

open access: yesToxicology Letters, 2016
Presentation for the British Pharmacological Society 'Pharmacology 2016' Meeting.https://www.bps.ac.uk/pharmacology2016Part of the Symposium 'Track 5: Organ-on-a-chip technology - the future of physiological profiling?'https://www.bps.ac.uk/pharmacology2016#Day ...
openaire   +2 more sources

Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair [PDF]

open access: yes, 2013
Tubular scaffolds which incorporate a variety of micro- and nanotopographies have a wide application potential in tissue engineering especially for the repair of spinal cord injury (SCI).
Bereiter-Hahn J.   +31 more
core   +3 more sources

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