Results 31 to 40 of about 133,158,617 (301)

Human Nonalcoholic Steatohepatitis on a Chip

Hepatology Communications, 2021
Nonalcoholic steatohepatitis (NASH), an advanced stage of nonalcoholic fatty liver disease (NAFLD), is a rapidly growing and global health problem compounded by the current absence of specific treatments. A major limiting factor in the development of new
May S. Freag, Bumseok Namgung, Maria E. Reyna Fernandez, Ermanno Gherardi, Shiladitya Sengupta, Hae Lin Jang   +5 more
doaj   +1 more source

3D Inkjet-Bioprinted Lung-on-a-Chip

, 2023
There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang, Taejeong Kwak (15334091), Hwa-Rim Lee, Wookyeom Kim (15334082), Sungjune Jung (3236640), Wookyeom Kim, Yunji Lee, Hwa-Rim Lee (9072215), Taejeong Kwak, Sungjune Jung, Yunji Lee (15334085), Dayoon Kang (15334088)   +11 more
core   +1 more source

Cylindrical core-shell tween 80 micelle templated green synthesis of gold-silver hollow cubic nanostructures as efficient nanocatalysts

Materials & Design, 2018
The non-ionic surfactant, Tween 80 (T80) a material with promising applications in the pharmaceutical, cosmetic, and food industries, has been explored here for the design of novel nanostructures (NS).
Dickson Joseph, Hoomin Lee, Yun Suk Huh, Young-Kyu Han   +3 more
doaj   +1 more source

Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

Nature Communications, 2021
Engineered bacteria (synthetic biotics) represent a new class of therapeutics that leverage the tools of synthetic biology. Translational testing strategies are required to predict synthetic biotic function in the human body.
M. T. Nelson, M. Charbonneau, Heidi G. Coia, M. Castillo, C. Holt, Eric S. Greenwood, P. Robinson, E. Merrill, David Lubkowicz, C. Mauzy   +9 more
semanticscholar   +1 more source

A Microfluidic Model of AQP4 Polarization Dynamics and Fluid Transport in the Healthy and Inflamed Human Brain: The First Step Towards Glymphatics-on-a-chip

Advances in Biology, 2022
Dysfunction of the aquaporin‐4 (AQP4)‐dependent glymphatic waste clearance pathway has recently been implicated in the pathogenesis of several neurodegenerative diseases.
Paul A. Soden, A. R. Henderson, Esak Lee
semanticscholar   +1 more source

Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

Journal of Cerebral Blood Flow and Metabolism, 2021
Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB) properties in dynamic conditions. We studied a BBB model, consisting of human endothelial cells derived from hematopoietic stem cells in co-culture with brain pericytes,
A. R. Santa-Maria, Fruzsina R. Walter, R. Figueiredo, András Kincses, Judit P. Vigh, M. Heymans, M. Culot, P. Winter, F. Gosselet, A. Dér, M. Deli   +10 more
semanticscholar   +1 more source

Organ-on-a-chip: recent breakthroughs and future prospects

BioMedical Engineering OnLine, 2020
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip.
Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen, Xiuqing Gong   +7 more
doaj   +1 more source

Organic Anion Transporting Polypeptide 2B1 in Human Fetal Membranes: A Novel Gatekeeper for Drug Transport During Pregnancy?

Frontiers in Pharmacology, 2021
Current intervention strategies have not been successful in reducing the risks of adverse pregnancy complications nor maternal and fetal morbidities associated with pregnancy complications.
Esha Ganguly, Ananth Kumar Kammala, Meagan Benson, Lauren S. Richardson, Lauren S. Richardson, Arum Han, Ramkumar Menon   +6 more
doaj   +1 more source

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Light: Science & Applications, 2021
In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic ...
E. Rank, Ryan Sentosa, Danielle J. Harper, Matthias Salas, Anna Gaugutz, D. Seyringer, S. Nevlacsil, A. Maese-Novo, M. Eggeling, P. Muellner, R. Hainberger, M. Sagmeister, J. Kraft, R. Leitgeb, W. Drexler   +14 more
semanticscholar   +1 more source

A global wire planning scheme for Network-on-Chip. [PDF]

, 2003
As technology scales down, the interconnect for on-chip global communication becomes the delay bottleneck. In order to provide well-controlled global wire delay and efficient global communication, a packet switched Network-on-Chip (NoC) architecture was ...
J. Liu, Tenhunen, Hannu, H Tenhunen, Liu, Jian, Zheng, Li-Rong, Pamunuwa, Dinesh, Liu, J., Zheng, L-R, Pamunuwa, Dinesh B., L-r Zheng, D. Pamunuwa, L.-R. Zheng, H. Tenhunen   +12 more
core   +4 more sources