Results 31 to 40 of about 274,960 (253)

The method to generate pulsatile circulatory fluid flow using microfluidics

MethodsX, 2021
Microfluidic chips provide versatile tools to mimic the biological effect of blood flow on pluripotent stem cells (PSC). This paper presents methods for the use of microfluidics to model embryonic circulation using differentiated PSC.
Jingjing Li, Osmond Lao, Robert E. Nordon   +2 more
doaj   +1 more source

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost, Soumya K. Srivastava   +1 more
doaj   +1 more source

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Microorganisms, 2020
Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense. In this study, we analyzed whether
Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S. Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer   +17 more
doaj   +1 more source

Towards establishing human body-on-a-chip systems

Stem Cell Research & Therapy, 2022
Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj   +1 more source

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

Frontiers in Bioengineering and Biotechnology, 2020
Microengineered systems provide an in vitro strategy to explore the variability of individual patient response to tissue engineering products, since they prefer the use of primary cell sources representing the phenotype variability.
Gabriele Nasello, Gabriele Nasello, Pilar Alamán-Díez, Jessica Schiavi, María Ángeles Pérez, Laoise McNamara, José Manuel García-Aznar   +6 more
doaj   +1 more source

Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. [PDF]

Adv Funct Mater, 2019
AbstractThe goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the human response to compounds within physiologically relevant platforms. The generation and characterization of such systems is currently a focal point of research given the long‐standing inadequacies of conventional techniques for predicting human outcome ...
Oleaga C, Lavado A, Riu A, Rothemund S, Carmona-Moran CA, Persaud K, Yurko A, Lear J, Narasimhan NS, Long CJ, Sommerhage F, Bridges LR, Cai Y, Martin C, Schnepper MT, Goswami A, Note R, Langer J, Teissier S, Cotovio J, Hickman JJ.   +20 more
europepmc   +3 more sources

ASSIST: Refinement of a Benefits Navigator Intervention Among Low‐Income Pediatric Oncology Families

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Children with cancer living in poverty experience worse survival and quality of life. Interventions connecting low‐income families to benefits (e.g., Supplemental Nutrition Assistance Program [SNAP] improve health outcomes; yet nearly 50% of SNAP‐eligible pediatric oncology families are unenrolled.
Puja J. Umaretiya, Selena Murcia Mendez, Jennifer Kellett, Sarah Wright, Marisel Ponton, Robin T. Higashi, Rahela Aziz‐Bose, Colleen A. Kelly, Ayesha Zia, Joanne Wolfe, Sandi L. Pruitt, Kira Bona   +11 more
wiley   +1 more source

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

Biochemical Journal, 2023
The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing ...
openaire   +2 more sources

Sociodemographic Factors Associated With Later Stage at Diagnosis of Pediatric Germ Cell Tumors: A Report From Children's Oncology Group Registries ACCRN07 and APEC14B1

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas, Judy Y. Ou, Todd Alonzo, Logan G. Spector, Negar Fallahazad, Emily Owens, Anne C. Kirchhoff, Adam L. Green   +7 more
wiley   +1 more source

HIV Biosensors - The Potential of the Electrochemical Way

International Journal of Electrochemical Science, 2014
Because of high costs and time consuming common HIV tests, new ways in diagnosis, offering rapid, cheap, and accuracy possibility are looking for. One of the most promising fields is electrochemistry, providing very good specifity, relatively low price ...
Miguel Angel Merlos Rodrigo, Zbynek Heger, Natalia Cernei, Ana Maria Jimenez Jinemez, Ondrej Zitka, Vojtech Adam, Rene Kizek   +6 more
doaj   +1 more source