Results 51 to 60 of about 133,158,617 (301)

Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.

Journal of Pharmacy and Science, 2021
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological architecture and flow.
M. Vormann, J. Vriend, H. Lanz, L. Gijzen, A. van den Heuvel, Simon Hutter, J. Joore, S. Trietsch, Christiaan Stuut, T. Nieskens, J. Peters, D. Ramp, M. Caj, F. Russel, Björn Jacobsen, A. Roth, Shu-Yan Lu, J. Polli, Anita A. Naidoo, P. Vulto, R. Masereeuw, M. Wilmer, L. Suter-Dick   +22 more
semanticscholar   +1 more source

Revolutionizing nephrology research: expanding horizons with kidney-on-a-chip and beyond

Frontiers in Bioengineering and Biotechnology
Organs-on-a-chip (OoC) is a microengineered three-dimensional cell culture system developed for decades. Utilizing microfluidic technology, OoC cultivates cells on perfusable channels to construct in vitro organ models, enabling the simulation of organ ...
Wei Huang, Yi-Yuan Chen, Fang-Fang He, Chun Zhang   +3 more
doaj   +1 more source

A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma

Nature Biomedical Engineering
Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models can be used to study microbiome–host crosstalk, yet their utility is constrained by substantial anatomical, functional, immunological and
M. Ballerini, Serena Galiè, Punit Tyagi, C. Catozzi, Hariam Raji, Amir Nabinejad, A. D. Macandog, A. Cordiale, Bianca Ionela Slivinschi, Karol K Kugiejko, Martina Freisa, P. Occhetta, J. Wargo, P. Ferrucci, E. Cocorocchio, N. Segata, Andrea Vignati, A. Morgun, M. Deleidi, Teresa Manzo, M. Rasponi, L. Nezi   +21 more
semanticscholar   +1 more source

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Microorganisms, 2020
Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense. In this study, we analyzed whether
Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S. Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer   +17 more
doaj   +1 more source

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Scientific Reports, 2018
Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip (Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal biopsies. The primary epithelial cells are expanded as 3D organoids, dissociated,
Magdalena Kasendra, Alessio Tovaglieri, Alexandra Sontheimer-Phelps, Sasan Jalili-Firoozinezhad, Amir Bein, Angeliki Chalkiadaki, W. Scholl, Cheng Zhang, H. Rickner, Camilla A. Richmond, Hu Li, D. Breault, D. Ingber   +12 more
semanticscholar   +1 more source

Engineering human islet organoids from iPSCs using an organ-on-chip platform

, 2019
Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for diabetes studies, cell replacement treatment and drug screening.
Li, Zhongyu, Qin, Jianhua, Su, Wentao, Wang, Yaqing, Guo, Yaqiong, Deng, Pengwei, Tao, Tingting, Chen, Wenwen   +7 more
core   +1 more source

Fast electrically assisted regeneration of on-chip SERS substrates

, 2022
S.2923-2927A microfluidic chip approach utilising integrated electrically connected stationary SERS targets based on inkjet-printed silver nanoparticles is presented.
Belder, Detlev, Kemper, F., Poehler, Elisabeth, Pabst, Oliver, Jahnke, Heinz-Georg, Beckert, Erik, Robitzki, Andrea Anneliese, Meier, T.-A.   +7 more
core   +1 more source

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost, Soumya K. Srivastava   +1 more
doaj   +1 more source

A systematic review with narrative synthesis on medical robotics and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu) viruses [PDF]

Journal of Health and Social Sciences, 2020
Introduction: Medical robotics is a rapidly growing aspect of the modern health care landscape. The aim of this paper was to review the availability of robotic technology and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu ...
Shantani KANNAN, Kannan SUBBARAM, Sheeza ALI, Hemalatha KANNAN   +3 more
doaj   +1 more source

Correction: 3D printed nervous system on a chip

, 2016
Correction for ‘3D printed nervous system on a chip’ by Blake N.
Meng, Fanben, Johnson, Blake N, McAlpine, Michael C, Lancaster, Karen Z, Enquist, Lynn W, Hogue, Ian B, Kong, Yong Lin   +6 more
core   +1 more source