Results 51 to 60 of about 270,658 (298)
The method to generate pulsatile circulatory fluid flow using microfluidics
MethodsX, 2021 Microfluidic chips provide versatile tools to mimic the biological effect of blood flow on pluripotent stem cells (PSC). This paper presents methods for the use of microfluidics to model embryonic circulation using differentiated PSC.
Jingjing Li +2 more
doaj +1 more source
From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics
Biochemical Journal, 2023 The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing ...
openaire +2 more sources
Maximizing the Impact of Microphysiological Systems with in Vitro–in Vivo Translation [PDF]
, 2018 Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here,
Cirit, Murat, Stokes, Cynthia L.
core +1 more source
A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications
BiosensorsOrgan-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost +1 more
doaj +1 more source
Microorganisms, 2020 Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense. In this study, we analyzed whether
Elisabeth Schicke +17 more
doaj +1 more source
Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj +1 more source
Living Cell Microarrays: An Overview of Concepts [PDF]
, 2016 Living cell microarrays are a highly efficient cellular screening system. Due to the low number of cells required per spot, cell microarrays enable the use of primary and stem cells and provide resolution close to the single-cell level.
Jonczyk, Rebecca +5 more
core +3 more sources
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources
Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism [PDF]
, 2014 Intelligent in vitro models able to recapitulate the physiological interactions between tissues in the body have enormous potential as they enable detailed studies on specific two-way or higher order tissue communication.
Arti Ahluwalia +2 more
core +2 more sources
Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright +13 more
wiley +1 more source