Results 41 to 50 of about 133,158,617 (301)

Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

Advanced Science, 2020
A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum‐free medium is developed. This in vitro platform can emulate
Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti‐LaPatki, Michael L. Shuler, James J. Hickman   +10 more
doaj   +1 more source

Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies

Marine Drugs, 2018
Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous ...
Vivek K. Bajpai, Shruti Shukla, Sung-Min Kang, Seung Kyu Hwang, Xinjie Song, Yun Suk Huh, Young-Kyu Han   +6 more
doaj   +1 more source

Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit‐on‐a‐Chip Model

Advanced Materials & Technologies, 2022
Given the multi‐tissue aspects of osteoarthritis (OA) pathophysiology, translation of OA susceptibility genes towards underlying biological mechanism and eventually drug target discovery requires appropriate human in vitro OA models that incorporate both
M. Tuerlings, I. Boone, Hossein Eslami Amirabadi, M. Vis, E. Suchiman, E. Linden, S. Hofmann, R. Nelissen, J. Toonder, Y. Ramos, I. Meulenbelt   +10 more
semanticscholar   +1 more source

From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

, 2020
We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing
Campos, C. D. M., Manz, A., Soon, J. B. W., Neužil, P., Reboud, J., Wong, C. C.   +5 more
core   +1 more source

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Nature Biomedical Engineering, 2019
The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living human intestinal cells and their
Sasan Jalili-Firoozinezhad, F. Gazzaniga, E. Calamari, Diogo M. Camacho, Cicely W. Fadel, Amir Bein, Ben Swenor, Bret A. Nestor, Michael J. Cronce, Alessio Tovaglieri, O. Levy, K. Gregory, D. Breault, J. M. Cabral, Dennis L. Kasper, R. Novák, D. Ingber   +16 more
semanticscholar   +1 more source

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

, 2022
S.1645-1654Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips.
Zushin, P.J.H., Healy, K.E., Stahl, A., Reese, W.M., Loskill, P., Lee-Montiel, F.T., Jeeawoody, S., Sezhian, T., Tharp, K.M.   +8 more
core   +1 more source

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Lab on a Chip, 2020
Traditional drug screening models are often unable to faithfully recapitulate human physiology in health and disease, motivating the development of microfluidic organs-on-a-chip (OOC) platforms that can mimic many aspects of human physiology and in the ...
Alan G Chramiec, Diogo Teles, K. Yeager, Alessandro Marturano-Kruik, Joseph Pak, Timothy Chen, Lu-Ke Hao, Miranda C. Wang, Roberta I. Lock, D. Tavakol, M. Lee, Jinho Kim, Kacey Ronaldson-Bouchard, G. Vunjak-Novakovic   +13 more
semanticscholar   +1 more source

The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials

, 2020
The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several ...
Bertassoni, Luiz E., Puppin Rontani, Regina Maria, Sereda, Grigoriy, Franca, Cristiane Miranda, Rodrigues, Nara Sousa, Tahayeri, Anthony, Ferdosian, Shirin, Ferracane, Jack L.   +7 more
core   +1 more source

Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis [PDF]

, 2010
The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) is an important regulator of hepatic lipid metabolism. While PPARalpha is known to activate transcription of numerous genes, no comprehensive picture of PPARalpha ...
Degenhardt, Tatjana, Merja Heinäniemi, Väisänen, Sami, Carlberg, Carsten, Carsten Carlberg, de Vries, Sacco C, Müller, M.R., David L. M. van der Meer, Vries, Sacco, de, Philip J. de Groot, Degenhardt, T., Kersten, Sander, Heinaniemi, M., Vries, S.C., de, Kersten, A.H., Müller, Michael, Carlberg, C., Meer, D.L., van der, Sander Kersten, Michael Müller, Meer, D.L.M., van der, Groot, Philip, de, Väisänen, S., Sami Väisänen, van der Meer, David L M, Groot, P.J., de, Heinäniemi, Merja, de Groot, Philip J, Tatjana Degenhardt, Sacco C. de Vries   +29 more
core   +1 more source

An immune-competent lung-on-a-chip for modelling the human severe influenza infection response

Nature Biomedical Engineering
Severe influenza affects 3–5 million people worldwide each year, resulting in more than 300,000 deaths annually. However, standard-of-care antiviral therapeutics have limited effectiveness in these patients. Current preclinical models of severe influenza
Rachel Ringquist, Eshant Bhatia, Paramita Chatterjee, Drishti Maniar, Zhou Fang, Page Franz, Liana Kramer, Delta Ghoshal, Neha Sonthi, Emma R. Downey, Joshua P. Canlas, Abigail Ochal, Savi Agarwal, Valeria A. Cuellar, Grace Harrigan, Ahmet F. Coskun, Ankur Singh, Krishnendu Roy   +17 more
semanticscholar   +1 more source