Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment [PDF]
, 2016 Organs-on-chips are three-dimensional, microfluidic cell culture systems that simulate the function of tissues and organ subunits. Organ-on-chip systems are expected to contribute to drug candidate screening and the reduction of animal tests in ...
Hummel, J. Marjan +6 more
core +8 more sources
Industrial lab-on-a-chip: Design applications and scale-up for drug discovery and delivery [PDF]
, 2013 journal ...
ICHIKAWA Sosaku +7 more
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The three-dimensional structure of human erythrocyte aquaporin CHIP. [PDF]
The EMBO Journal, 1994 Water-permeable membranes of several plant and mammalian tissues contain specific water channel proteins, the 'aquaporins'. The best characterized aquaporin is CHIP, a 28 kDa red blood cell channel-forming integral protein. Isolated CHIP and Escherichia coli lipids may be assembled into 2-D crystals for structural analyses.
Walz, T. +3 more
openaire +2 more sources
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]
, 2018 Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan +37 more
core +2 more sources
An innovative phase 2 proof-of-concept trial design to evaluate SAR445088, a monoclonal antibody targeting complement C1s in chronic inflammatory demyelinating polyneuropathy [PDF]
, 2023 Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nerves, with significant unmet treatment needs. Clinical trials in CIDP are challenging; thus, new trial designs are needed. We present design of
Alonso-Alonso, Miguel +9 more
core +5 more sources
A systematic review with narrative synthesis on medical robotics and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu) viruses [PDF]
Journal of Health and Social Sciences, 2020 Introduction: Medical robotics is a rapidly growing aspect of the modern health care landscape. The aim of this paper was to review the availability of robotic technology and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu ...
Shantani KANNAN +3 more
doaj +1 more source
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans [PDF]
, 2015 Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults.
Bakan, Ahmet +14 more
core +1 more source
Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices [PDF]
, 2021 Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products.
Cawthorne, Chris +4 more
core +3 more sources
Revolutionizing nephrology research: expanding horizons with kidney-on-a-chip and beyond
Frontiers in Bioengineering and BiotechnologyOrgans-on-a-chip (OoC) is a microengineered three-dimensional cell culture system developed for decades. Utilizing microfluidic technology, OoC cultivates cells on perfusable channels to construct in vitro organ models, enabling the simulation of organ ...
Wei Huang +3 more
doaj +1 more source
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
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