Results 21 to 30 of about 270,658 (298)

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]

, 2016
© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson, Ananthakrishnan A. N., C. Dyer, Itzkowitz S. H., J. Davies, J. Greenman, J. Macfie, L. Karsai, M. Jacobsen, Ponder A., Rodrigues E., Triantafillidis J. K.   +11 more
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Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
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Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput [PDF]

, 2013
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Marx, Uwe, Materne, Eva-Maria, Tonevitsky, Alexander G.   +2 more
core   +1 more source

Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]

, 2020
Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick, Chaudhuri, Ovijit, Engler, Adam J, Huang, Ngan F, Khademhosseini, Ali, Kumar, Sanjay, Li, Song, Wang, Aijun, Wang, Yingxiao   +8 more
core   +2 more sources

Integrating biological vasculature into a multi-organ-chip microsystem [PDF]

, 2013
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Brincker, Sven, Busek, Mathias, Groth, Benjamin, Hoffmann, Silke, Horland, Reyk, Lauster, Roland, Lindner, Gerd, Lorenz, Alexandra, Marx, Uwe, Menzel, Ulrike, Schimek, Katharina, Sonntag, Frank, Walles, Heike   +12 more
core   +2 more sources

Organ-on-a-chip: recent breakthroughs and future prospects

BioMedical Engineering OnLine, 2020
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip.
Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen, Xiuqing Gong   +7 more
doaj   +1 more source

Chip-based human liver-intestine and liver-skin co-culture : A first step toward systemic repeated dose substance testing in vitro [PDF]

, 2015
Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives.
Ayehunie, Seyoum, Garbe, Leif-Alexander, Hasenberg, Tobias, Hayden, Patrick, Jaenicke, Annika, Lauster, Roland, Lindner, Marcus, Lorenz, Alexandra Katharina, Marx, Uwe, Maschmeyer, Ilka, Materne, Eva-Maria, Sonntag, Frank, Zech, Julie   +12 more
core   +1 more source

Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip

Frontiers in Cell and Developmental Biology, 2022
Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology.
Bolin Jing, Bolin Jing, Kun Xia, Chen Zhang, Siming Jiao, Limeng Zhu, Jinhua Wei, Zhuo A. Wang, Nannan Chen, Pengfei Tu, Jianjun Li, Yuguang Du   +11 more
doaj   +1 more source

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]

, 2015
Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie, Drewell, Christopher, Hasenberg, Tobias, Hübner, Juliane, Lauster, Roland, Lindner, Marcus, Lorenz, Alexandra K., Marx, Uwe, Maschmeyer, Ilka, Ramme, Anja P., Sambo, Naomia Sisoli, Schimek, Katharina, Sonntag, Frank, Thomas, Alexander   +13 more
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Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

Advanced Science, 2020
A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum‐free medium is developed. This in vitro platform can emulate
Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti‐LaPatki, Michael L. Shuler, James J. Hickman   +10 more
doaj   +1 more source