Results 21 to 30 of about 133,158,617 (301)
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2022 S.2688-2699Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied
Drewell, Christopher +13 more
core +2 more sources
Nature Biomedical Engineering, 2021 The rapid repurposing of antivirals is particularly pressing during pandemics. However, rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines that do not recapitulate human physiology at the tissue and organ levels.
L. Si +37 more
semanticscholar +1 more source
Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
Science Advances, 2022 Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease ...
Ken Hiratsuka +8 more
semanticscholar +1 more source
Bioinspired human stomach-on-a-chip with in vivo like function and architecture.
Lab on a Chip, 2023 The lack of biomimetic in vitro models capable of reproducing the complex architecture and the dynamic environment of the gastric mucosa, delay the development of diagnostic and therapeutic tools.
D. Ferreira +5 more
semanticscholar +1 more source
On-chip perivascular niche supporting stemness of patient-derived glioma cells in a serum-free, flowable culture [PDF]
, 2021 Glioblastoma multiforme (GBM) is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem-like cells (GSCs) can migrate in vascular niches within or away from the tumour mass, increasing tumour resistance to treatments ...
Gerigk, M +23 more
core +1 more source
Journal of Clinical Medicine, 2023 Quantification of fetal drug exposure remains challenging since sampling from the placenta or fetus during pregnancy is too invasive. Currently existing in vivo (e.g., cord blood sampling) and ex vivo (e.g., placenta perfusion) models have inherent ...
F. Elzinga +9 more
semanticscholar +1 more source
Organ-On-A-Chip: An Emerging Research Platform
Organogenesis, 2023 In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology.
Nithin R +4 more
doaj +1 more source
JCI Insight, 2023 Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut barrier disruption ...
Wyatt E. Lanik +17 more
semanticscholar +1 more source
Frontiers in Toxicology, 2022 Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of oral mucosa to metals, which are known to activate the immune system and in turn may result in ...
Jasper J. Koning +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik +6 more
semanticscholar +1 more source