Results 11 to 20 of about 274,960 (253)
Multi-Sensors Integration in a Human Gut-On-Chip Platform [PDF]
Proceedings, 2018 In the conventional culture systems in vitro, the challenging organoid approach have recently been overcome by the development of microfluidic Organ Chip models of human intestine.
Lucia Giampetruzzi +6 more
doaj +5 more sources
Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions. [PDF]
Micromachines (Basel), 2021 For centuries, animal experiments have contributed much to our understanding of mechanisms of human disease, but their value in predicting the effectiveness of drug treatments in the clinic has remained controversial. Animal models, including genetically modified ones and experimentally induced pathologies, often do not accurately reflect disease in ...
Pun S, Haney LC, Barrile R.
europepmc +5 more sources
Human Organs-on-Chips for Virology [PDF]
Trends in Microbiology, 2020 While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking.
Tang, H. +6 more
openaire +4 more sources
The ethical aspects of human organ-on-chip models: A mapping review. [PDF]
Stem Cell ReportsOrgan-on-chips (OoCs) are controlled microfluidic platforms that replicate specific organ-level functionalities and pathological processes using cultured cells. OoCs promise to enhance drug discovery, reduce dependence on animal models, and enable personalized treatments. However, OoCs also introduce ethical challenges.
Weidema J +3 more
europepmc +3 more sources
Investigations on T cell transmigration in a human skin-on-chip (SoC) model. [PDF]
Lab Chip, 2021 Our skin-on-chip (SoC) model uniquely enabled quantitative studies of transendothelial and transepithelial migration of human T lymphocytes under mimicked inflammatory skin conditions and was used to test new drug candidates.
Ren X +10 more
europepmc +5 more sources
A human-on-a-chip approach to tackling rare diseases. [PDF]
Drug Discov Today, 2019 Drug development for rare diseases, classified as diseases with a prevalence of < 200 000 patients, is limited by the high cost of research and low target population. Owing to a lack of representative disease models, research has been challenging for orphan drugs.
de Mello CPP +3 more
europepmc +4 more sources
Advances in human organoids-on-chips in biomedical research
Life Medicine, 2023 AbstractOrganoids-on-chips is opening up new frontier of research in biomedical field by combining organoids and organs-on-chips technology. The integrative technology offers great opportunities to maximize the potentials of organoids with higher fidelity, thus building advanced organ model systems in a physiologically relevant manner.
Wang, Yaqing, Qin, Jianhua
openaire +2 more sources
SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip. [PDF]
Sci Bull (Beijing), 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. Clinical evidence suggests that the intestine is another high-risk organ for SARS-CoV-2 infection besides the lungs.
Guo Y +13 more
europepmc +3 more sources
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform. [PDF]
Adv Sci (Weinh)AbstractGalactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective measures against space travel exposures.
Tavakol DN +17 more
europepmc +4 more sources