Results 11 to 20 of about 133,158,617 (301)
Frontiers in Cell and Developmental Biology, 2022 Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology.
Bolin Jing +11 more
doaj +2 more sources
A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics [PDF]
Frontiers in Cell and Developmental Biology, 2021 Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness ...
Virginia M. Smith +7 more
doaj +2 more sources
Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. [PDF]
Adv Funct Mater, 2019 The goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the human response to compounds within physiologically relevant platforms.
Oleaga C +20 more
europepmc +2 more sources
Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. [PDF]
Biomaterials, 2018 Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully represent physiology, often lacking xenobiotic metabolism.
Oleaga C +23 more
europepmc +2 more sources
Reversed-engineered human alveolar lung-on-a-chip model
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance This work reports the development of a physiologically relevant human alveolar lung-on-a-chip model, composed of a three-dimensional (3D) porous hydrogel made of gelatin methacryloyl (GelMA) featuring an inverse opal structure, bonded to a ...
Weijia Zhang, Di Huang, Ting-Ting Liu
exaly +2 more sources
Cystic Fibrosis Human Organs-on-a-Chip
Micromachines, 2021 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most ...
Herbert Luke Ogden +4 more
doaj +2 more sources
Integrating biological vasculature into a multi-organ-chip microsystem [PDF]
, 2022 S.3588-3598A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale.
Lindner, G. +12 more
core +2 more sources
Human brain organoid-on-a-chip to model prenatal nicotine exposure.
Lab on a Chip, 2018 Nicotine has been recognized to trigger various neuronal disabilities in the fetal brain and long-lasting behavioral deficits in offspring. However, further understanding of fetal brain development under nicotine exposure is challenging due to the ...
Yaqing Wang +3 more
semanticscholar +2 more sources
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj +7 more sources
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source