A Real-Time Sensing System for Monitoring Neural Network Degeneration in an Alzheimer's Disease-on-a-Chip Model. [PDF]
Pharmaceutics, 2022 Stem cell-based in vitro models may provide potential therapeutic strategies and allow drug screening for neurodegenerative diseases, including Alzheimer’s disease (AD). Herein, we develop a neural stem cell (NSC) spheroid-based biochip that is characterized by a brain-like structure, well-defined neural differentiation, and neural network formation ...
Liu NC, Liang CC, Li YE, Lee IC.
europepmc +4 more sources
Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells. [PDF]
Sci Rep, 2020 AbstractDisease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic and their response to an applied stress is highly dependent on the magnitude and ...
Armistead FJ +4 more
europepmc +9 more sources
Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models. [PDF]
J Hazard MaterMicro and nanoplastics (MNPs) are widespread environmental and food web contaminants that are absorbed by the intestine and distributed systemically, but the mechanisms of uptake are not well understood. In a triculture small intestinal epithelial model, we previously found that uptake of 26 nm polystyrene MNPs (PS26) occurred by both passive diffusion
Kharaghani D +10 more
europepmc +3 more sources
Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform. [PDF]
Front Cardiovasc MedBackground Early-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL). Worldwide studies have revealed that aortic valve disease accounts for up to 43%
Mendoza-Seale M +3 more
europepmc +3 more sources
Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model. [PDF]
Mater Today BioGold nanoparticles (GNP) are highly valuable in nanotechnology due to their biocompatibility and unique physicochemical properties, which make them attractive as nanocarriers for targeted drug delivery. In the context of neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), GNP hold promise for reducing the toxicity of Amyloid-β peptide ...
Arellano A +16 more
europepmc +4 more sources
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine. [PDF]
Front Pharmacol, 2023 Cruz A +4 more
europepmc +4 more sources
Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects. [PDF]
Nat Biomed EngÖzkan A +17 more
europepmc +2 more sources
Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
doaj +1 more source
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj +7 more sources
Corrigendum to "Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model" [Mater. Today Bio 35 (2025) 102453]. [PDF]
Mater Today BioArellano A +16 more
europepmc +3 more sources