Results 61 to 70 of about 204,111 (283)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
BiomimeticsThe liver is a vital organ responsible for a broad range of metabolic functions, including glucose and lipid metabolism, detoxification, and protein synthesis.
Jingyeong Yun +2 more
doaj +1 more source
Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
Drug Discovery Today, 2016 In recent years, advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as organoid-on-a-chip platforms.
A. Skardal, T. Shupe, A. Atala
semanticscholar +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice
Science Translational Medicine, 2012 An in vitro model of human pulmonary edema predicts drug toxicity and efficacy previously observed in humans. Pulmonary Edema-on-a-Chip Drug testing in animal models is time-consuming, costly, and often does not accurately predict the adverse effects in ...
D. Huh +8 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microfluidic platform for understanding Parkinson’s disease and α-synuclein conformation
Translational NeurodegenerationMicrofluidic systems are an innovative engineering solution that is increasingly being used in a wide range of scientific fields. These systems use fluids in microchannels (1 to 300 microns) to analyze extremely small volumes of sample and reagent ...
Tregub Pavel +6 more
doaj +1 more source
Progress in the Application of Organoids-On-A-Chip in Diseases
OrganogenesisWith the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development.
Qiao Geng +6 more
doaj +1 more source
Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device
PLoS ONE, 2016 Background and Aim Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease worldwide, ranging from simple steatosis to nonalcoholic steatohepatitis, which may progress to cirrhosis, eventually leading to hepatocellular carcinoma (HCC).
M. Gori +5 more
semanticscholar +1 more source