Results 81 to 90 of about 92,114,249 (286)

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science
The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions.
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
doaj   +1 more source

Perspectives on organ-on-a-chip technology for natural products evaluation

Food & Medicine Homology
Natural products have always been a treasure trove for clinical drug development and a source of inspiration for lead compounds in the process of new drug discovery.
Xin Wang, Yu-Hang Miao, Xiao-Min Zhao, Xin Liu, Yan-Wei Hu, Da-Wei Deng   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Numerical and experimental study of a droplet-based PCR chip

, 2007
A two-temperature continuous-flow polymerase chain reaction (PCR) polymer chip has been constructed that takes advantage of droplet technology to avoid sample contamination and adsorption at the surface.
MacAskill, Alexandra, Goddard, N.J., Emerson, David, Macaskill A, Emerson DR, Day, P. J R, Fielden, P. R., Emerson, D. R., Zhang, Y. H., Mohr S, Day, Philip; id_orcid, Day PJR, Barber RW, Fielden, P.R., Barber, R. W., Zhang YH, Zhang, Yonghao, Goddard NJ, Goddard, N. J., Barber, Robert W., Macaskill, A., Mohr, S., Fielden PR, Day, P.J.R.   +23 more
core   +1 more source

A global wire planning scheme for Network-on-Chip. [PDF]

, 2003
As technology scales down, the interconnect for on-chip global communication becomes the delay bottleneck. In order to provide well-controlled global wire delay and efficient global communication, a packet switched Network-on-Chip (NoC) architecture was ...
J. Liu, Tenhunen, Hannu, H Tenhunen, Liu, Jian, Zheng, Li-Rong, Pamunuwa, Dinesh, Liu, J., Zheng, L-R, Pamunuwa, Dinesh B., L-r Zheng, D. Pamunuwa   +10 more
core   +1 more source

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

Gut Microbes, 2020
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin, Landon A. Hackley, Hyun Jung Kim   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A programmable microsystem using system-on-chip for real-time biotelemetry [PDF]

, 2005
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip microelectronics to design an integrated circuit instrument ...
Johannessen, E.A., Reid, S.W.J., Hammond, P.A., Cui, L., Cooper, J.M., Cumming, D.R.S., Wang, L.   +6 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

, 2018
Liver organoids derived from human pluripotent stem cells (PSCs) represent a new type of in vitro liver model for understanding organ development, disease mechanism and drug testing.
Qin, Jianhua, Wang, Yaqing, Wang, Hui, Guo, Yaqiong, Deng, Pengwei, Chen, Wenwen, Tao, Tingting   +6 more
core   +1 more source