Results 101 to 110 of about 204,111 (283)

Construction of in vitro liver-on-a-chip models and application progress

BioMedical Engineering OnLine
The liver is the largest internal organ of the human body. It has a complex structure and function and plays a vital role in drug metabolism. In recent decades, extensive research has aimed to develop in vitro models that can simulate liver function to ...
Jie Liu, Yimei Du, Xinxin Xiao, Daopeng Tan, Yuqi He, Lin Qin   +5 more
doaj   +1 more source

Bone-on-a-Chip Systems for Hematological Cancers

Biosensors
Hematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, and myeloma, which necessitate the use of a distinct chemotherapeutic approach.
Gül Kozalak, Ali Koşar
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier.

Lab on a Chip
The incidence of inflammatory bowel disease among the elderly has significantly risen in recent years, posing a growing socioeconomic burden to aging societies. Moreover, non-gastrointestinal diseases, also prevalent in this demographic, have been linked
Konstanze Brandauer, Alexandra Lorenz, S. Schobesberger, P. Schuller, M. Frauenlob, Sarah Spitz, Peter Ertl   +6 more
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform

Proceedings of the National Academy of Sciences of the United States of America
Significance Our study demonstrates the adverse effects of spaceflight on an automated heart-on-a-chip platform sent to the International Space Station.
Devin B Mair, Jonathan H Tsui, Ty Higashi, Paul Koenig, Zhipeng Dong, Jeffrey F Chen, Jessica U Meir, A. S. T. Smith, Peter H U Lee, E. Ahn, Stefanie Countryman, N. Sniadecki, Deok-Ho Kim   +12 more
semanticscholar   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Recent Developments in Glioblastoma-on-a-chip for Advanced Drug Screening Applications

Small
Glioblastoma (GBM) is an aggressive form of cancer, comprising approximately 80% of malignant brain tumors. However, there are no effective treatments for GBM due to its heterogeneity and the presence of the blood-brain barrier (BBB), which restricts the
Surjendu Maity, T. Bhuyan, Christopher Jewell, Satoru Kawakita, Saurabh Sharma, Huu Tuan Nguyen, A. Hassani Najafabadi, M. Ermis, Natashya Falcone, Junjie Chen, K. Mandal, Danial Khorsandi, Can Yilgor, Auveen Choroomi, Emily F. Torres, Marvin Mecwan, Johnson V. John, Mohsen Akbari, Zhaohui Wang, Diogo Moniz-Garcia, Alfredo Quinones-Hinojosa, V. Jucaud, M. Dokmeci, A. Khademhosseini   +23 more
semanticscholar   +1 more source