Results 101 to 110 of about 195,333 (281)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Prototype development of a novel bio-mimetic Lab-On-Chip for studying cancer metastasis in the breast ductal system. [PDF]
, 2018 Thesis. M.E. American University of Beirut. Department of Mechanical Engineering, 2018. ET:6861.Advisor : Dr. Ramsey Hamade, Professor, Mechanical Engineering ; Co-Advisor : Dr.
Malaeb, Waddah Arkan
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Construction of in vitro liver-on-a-chip models and application progress
BioMedical Engineering OnLineThe liver is the largest internal organ of the human body. It has a complex structure and function and plays a vital role in drug metabolism. In recent decades, extensive research has aimed to develop in vitro models that can simulate liver function to ...
Jie Liu +5 more
doaj +1 more source
Entwicklung von mikrofluidischen Multi-Organ-Zellchipsystemen für die in vitro Metabolisierung und Bestimmung der Toxizität von Substanzen [PDF]
, 2018 Die Entwicklung neuer Arzneistoffe ist ein langer und kostenintensiver Prozess. Verlässliche experimentelle Modelle zur präklinischen Testung während frühen Phasen der Arzneistoffentwicklung sind essenziell, um einem späteren Misserfolg vorzubeugen ...
Theobald, Jannick Florian
core +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Investigating the Impact of LncRNAs PUNISHER and GAS5 on the Pathogenesis of Calcific Aortic Valve Disease [PDF]
Calcific aortic valve disease (CAVD) is a progressive disorder marked by fibrosis and calcification of the aortic valve, lacking effective pharmacological treatment.
Zhou, Yuan
core
DEVELOPMENT OF HUMAN TISSUES ON A CHIP FROM PLURIPOTENT STEM CELLS [PDF]
, 2014 The development of new microscale technologies aimed at generating human tissues and organs on a chip is emerging as a novel effective strategy to perform cost effective and multi-parametric assays for disease modeling investigations and screening ...
Michielin, Federica
core +1 more source
Exploring Novel Materials To Be Used As Dual-Energy Mammography Contrast Agents For Breast Cancer Detection [PDF]
, 2022 Dual-energy mammography (DEM) is a recently FDA-approved x-ray imaging technology developed for breast cancer screening, especially advantageous for women with dense breasts.
Nieves Lopez, Lenitza
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source