Results 121 to 130 of about 204,111 (283)

Advancing Blood–Brain Barrier-on-a-Chip Models Through Numerical Simulations

BioChip Journal
Researchers have placed engineered or natural tissues within microfluidic chips originating the so-called organ-on-a-chip (OoC) devices. With this technology, organ models can be subjected to phenomena that replicate the complex in vivo biological ...
V. Carvalho, Raquel O. Rodrigues, S. Shin, Rui A. Lima, Senhorinha Teixeira   +4 more
semanticscholar   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Saliva Lab-on-a-chip biosensors: Recent novel ideas and applications in disease detection

, 2021
M. Mohammadi, Sterre Mulder, P. Khashayar, A. Kalbasi, M. Azimzadeh, A. Aref   +5 more
semanticscholar   +1 more source

Revolutionizing respiratory health research: “commercially-available lung-on-a-chip and air-liquid interface systems”

Frontiers in Lab on a Chip Technologies
Inhalation of ultrafine particles, aerosol contaminants, and cigarette smoke can induce respiratory diseases. As humans are constantly exposed to various exogenous substances, it is crucial to study their impacts on respiratory diseases and airway ...
Sohyun Park, Chang Gyu Woo, Young-Jae Cho   +2 more
semanticscholar   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A critical appraisal of drug transport across the blood-brain barrier: Evaluation using new-age microfluidic technique

Brain Research Bulletin
Research over the past few decades has focused on elucidating the role of the blood-brain barrier (BBB) in neuroprotection, regulation of the brain microenvironment, and mediation of the selective permeability of substances, including drug molecules ...
Kiran Marathe, Dhruv Sanjay Gupta, Kalyani Barve, Dhananjay Bodas   +3 more
doaj   +1 more source

Monitoring of Electrophysiological Functions in Brain‐on‐a‐Chip and Brain Organoids

Advanced NanoBiomed Research
Though animal models are still the gold standard for fundamental biological studies and drug evaluation for brain diseases, concerns arise from an apparent lack of reflecting the human genetics and pathophysiology.
Jiyoung Song, Hoon Eui Jeong, A. Choi, Hongnam Kim   +3 more
semanticscholar   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

Integrating Patient‐Reported Quality Measures in Systemic Lupus Erythematosus: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, EarlyView.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcome measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semistructured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M. Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Organ-on-a-Chip Applications in Microfluidic Platforms

Micromachines
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication
Ling An, Yi Liu, Yaling Liu
doaj   +1 more source