Results 81 to 90 of about 133,158,617 (301)

Human tendon-on-a-chip for modeling the myofibroblast microenvironment in peritendinous fibrosis

Advanced Healthcare Materials
Understanding the myofibroblast microenvironment is critical to developing therapies for fibrotic diseases. Here the development of a novel human tendon‐on‐a‐chip (hToC) is reported to model this crosstalk in peritendinous adhesions, which currently ...
Raquel E. Ajalik, Isabelle Linares, Rahul G. Alenchery, Victor Z Zhang, Terry W. Wright, Benjamin L. Miller, James L. McGrath, Hani A. Awad   +7 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications

, 2020
Polydimethylsiloxane (PDMS) is among the most widely used materials for organ-on-chip systems. Despite itsmultiple beneficial characteristics from an engineering point of view, there is a concern about the effect of PDMSon the cells cultured in such ...
Carter, Sarah-Sophia,, Kadekar, Sandeep,, Atif, Abdul Raouf,, Varghese, Oommen P., Mestres, Gemma,, Carter, Sarah-Sophia, Tenje, Maria,, Engqvist, Håkan, Varghese, Oommen P.,, Tenje, Maria, Kadekar, Sandeep, Engqvist, Håkan,, Atif, Abdul Raouf, Lanekoff, Ingela, Lanekoff, Ingela,, Mestres, Gemma   +15 more
core   +1 more source

Low-cost on-chip clock jitter measurement scheme [PDF]

, 2014
In this paper, we present a low-cost, on-chip clock jitter digital measurement scheme for high performance microprocessors. It enables in situ jitter measurement during the test or debug phase.
Giaffreda, Daniele, Rahman A., Omana, Martin, Rossi D., Tam, S., Omana M., Omana, M., Metra C., Metra, C., Mak, TM, Rahman, A., Rossi, Daniele, S. Tam, Giaffreda, D., Metra, Cecilia, Raman, Asifur, A. Rahman, Mak, T.M., Mak T. M., D. Giaffreda, TM Mak, Giaffreda D., Tam, Simon, Tam S., OMANA, MARTIN EUGENIO, Rossi, D.   +25 more
core   +1 more source

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Micromachines, 2021
Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye, Rohan Bhattacharya, Xingrui Mou, Yuhao Zhou, Morgan A. Burt, Samira Musah   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Perspectives on organ-on-a-chip technology for natural products evaluation

Food & Medicine Homology
Natural products have always been a treasure trove for clinical drug development and a source of inspiration for lead compounds in the process of new drug discovery.
Xin Wang, Yu-Hang Miao, Xiao-Min Zhao, Xin Liu, Yan-Wei Hu, Da-Wei Deng   +5 more
doaj   +1 more source

Thromboinflammation Model-on-A-Chip by Whole Blood Microfluidics on Fixed Human Endothelium

Diagnostics, 2021
Microfluidic devices have an established role in the study of platelets and coagulation factors in thrombosis, with potential diagnostic applications. However, few microfluidic devices have assessed the contribution of neutrophils to thrombus formation ...
Alexander Dupuy, Lejla Hagimola, Neil S A Mgaieth, C. Houlahan, R. E. Preketes-tardiani, Paul Coleman, F. Passam   +6 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Label-Free Quantification of Asymmetric Cancer-Cell Filopodium Activities in a Multi-Gradient Chip

, 2011
We use novel super-resolution bright-field optical microscopy to observe the filopodium activities of human lung cancer cells in a multi-gradient cell culture chip. Temporal variations of the filopodium numbers are measured without fluorescent labelling.
HSU, TSI-HSUAN;YEN, MENG-HUA;LIAO, WEI-YU;CHENG, JI-YEN;LEE, CHAU-HWANG, 許慈軒;顏孟華;廖唯昱;鄭郅言;李超煌   +1 more
core   +1 more source