Non-Alcoholic Fatty Liver Disease and the Gut Microbiome: The Effects of Gut Microbial Metabolites on NAFLD Progression in a 2-Organ Human-on-a-Chip Model [PDF]
, 2020 Using a novel, adipose-liver, two-organ, human-on-a-chip system, the metabolic disease non-alcoholic fatty liver disease was modeled. This model was then used to test the effects of the gut microbiome on NAFLD progression.
Boone, Rachel H
core +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Advanced Functional Materials, EarlyView.Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
Scientific ReportsPreclinical methods are needed for screening potential Alzheimer’s disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease.
Julbert Caneus +9 more
doaj +1 more source
Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease. [PDF]
Nat Commun, 2022 Li SR +7 more
europepmc +1 more source
MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance
Advanced Functional Materials, EarlyView.Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley +1 more source
BiosensorsStatic well plates remain the gold standard to study viral infections in vitro, but they cannot accurately mimic dynamic viral infections as they occur in the human body.
Juliane Fjelrad Christfort +4 more
doaj +1 more source
Hot‐Film and Calorimetric Methods With Transient Heating for Measurement of High Biofluid Flow Rate
Advanced Functional Materials, EarlyView.Accurate measurement of biofluid flow rate is vital for clinical diagnostics. We propose a transient heating strategy using short thermal pulses and peak temperature tracking to enhance the flow sensitivity of the hot‐Film and calorimetric methods. Simulations show how optimal heating time maximizes sensitivity across flow rates.
Yuanting Wei +8 more
wiley +1 more source
Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine
JHEP ReportsBackground & Aims: Cholangiocarcinoma (CCA) is a primary liver tumour characterised by a poor prognosis and limited therapeutic options. Available 3D human CCA models fail to faithfully recapitulate the tumour niche. We aimed to develop an innovative
Michela Anna Polidoro +14 more
doaj +1 more source
Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. [PDF]
Int J Mol Sci, 2023 Gabriel-Segard T +11 more
europepmc +1 more source
THE FUTURE AND PROSPECTS OF BIO-CHIPS [PDF]
, 2014 Nanotechnology deals with manipulation of matter at atomic and molecular level. A general description for nanotechnology is provided by National Nanotechnology Initiative, that defines nanotechnology as the manipulation of matter with at least one ...
Pratibha, . +3 more
core +1 more source