Results 161 to 170 of about 133,158,617 (301)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Human Gut-on-a-Chip microfluidic culture device.

, 2017
Photograph (A) and schematic diagram (B) of the human Gut-on-a-Chip device. (C) Phase contrast micrograph of human Caco-2 intestinal epithelial cells cultured for 6 days in a Gut-on-a-Chip under apical flow (30μl/hr; 0.02 dyne.cm-2) and cyclic mechanical
Tiama Hamkins-Indik (3712198), Christopher A. Elkins (3387590), Samantha Q. Wales (3712204), Anthony Bahinski (3712207), James C. Weaver (1775959), Thomas C. Ferrante (335338), Michael Kulka (3712201), Efstathia Papafragkou (417823), Donald E. Ingber (10383), Remi Villenave (2723311)   +9 more
core   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

Centrifugal Microfluidic Cell Culture Platform for Physiologically Relevant Virus Infection Studies: A Case Study with HSV-1 Infection of Periodontal Cells

Biosensors
Static well plates remain the gold standard to study viral infections in vitro, but they cannot accurately mimic dynamic viral infections as they occur in the human body.
Juliane Fjelrad Christfort, Morgane Ortis, Hau Van Nguyen, Robert Marsault, Alain Doglio   +4 more
doaj   +1 more source

A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation. [PDF]

Lab Chip, 2023
Kraus S, Lee E.
europepmc   +1 more source

Human‐on‐a‐Chip Systems: Long‐Term Electrical and Mechanical Function Monitoring of a Human‐on‐a‐Chip System (Adv. Funct. Mater. 8/2019)

Advanced Functional Materials, 2019
C. Oleaga, Andrea Lavado, A. Riu, Sandra Rothemund, Carlos A. Carmona-Moran, K. Persaud, Andrew Yurko, J. Lear, N. S. Narasimhan, Christopher J. Long, F. Sommerhage, L. R. Bridges, Yun-Qing Cai, Candace Martin, Mark T. Schnepper, A. Goswami, R. Note, Jessica Langer, S. Teissier, J. Cotovio, J. Hickman   +20 more
semanticscholar   +1 more source

Cancer-on-a-chip for precision cancer medicine

Lab on a Chip
Many cancer therapies fail in clinical trials despite showing potent efficacy in preclinical studies. One of the key reasons is the adopted preclinical models cannot recapitulate the complex tumor microenvironment (TME) and reflect the heterogeneity and ...
Lunan Liu, Huishu Wang, Ruiqi Chen, Yujing Song, William I. Wei, David Baek, Mahan Gillin, K. Kurabayashi, Wei-Qiang Chen   +8 more
semanticscholar   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine

JHEP Reports
Background & Aims: Cholangiocarcinoma (CCA) is a primary liver tumour characterised by a poor prognosis and limited therapeutic options. Available 3D human CCA models fail to faithfully recapitulate the tumour niche. We aimed to develop an innovative
Michela Anna Polidoro, Erika Ferrari, Cristiana Soldani, Barbara Franceschini, Giuseppe Saladino, Arianna Rosina, Andrea Mainardi, Francesca D’Autilia, Nicola Pugliese, Guido Costa, Matteo Donadon, Guido Torzilli, Simona Marzorati, Marco Rasponi, Ana Lleo   +14 more
doaj   +1 more source

Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease. [PDF]

Nat Commun, 2022
Li SR, Gulieva RE, Helms L, Cruz NM, Vincent T, Fu H, Himmelfarb J, Freedman BS.   +7 more
europepmc   +1 more source