Results 171 to 180 of about 6,271,732 (295)

What evidence exists on the impacts of human activities on biodiversity and carbon capacity in North-East Atlantic blue carbon ecosystems: a systematic map protocol. [PDF]

Environ Evid
Kebir Z, Hausner VH, Lennert AE, Poste A, de Los Santos CB.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vulnerability Assessment of Six Endemic Tibetan-Himalayan Plants Under Climate Change and Human Activities. [PDF]

Plants (Basel)
Wei JD, Wang WT.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Assessing the impacts of climate change and human activities on distribution of Lophatherum gracile in China using the maxent model. [PDF]

Sci Rep
Lu Z, Wang G, Shao Y, Yan L, Huang L, Fan Z, Han S, Ren X, Han R, Zhang C, Ou J, Tong X.   +11 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Effect of land use, geology, and seasonality on hydrogeochemical baseline variations in a watershed impacted by human activities in the eastern Amazon. [PDF]

Environ Monit Assess
Salomão GN, Dall'Agnol R, de Almeida GS, Amarante RT, Mello GM, da Silva Júnior RO, Guimarães JTF, da Silva MS, Ferreira DM, Pontes PRM, Sahoo PK, Marques ED, da Silva Filho EV.   +12 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

NDVI based vegetation dynamics and responses to climate change and human activities at Xinjiang from 2001 to 2020. [PDF]

Sci Rep
Lu Y, Yu Y, Sun L, Li C, He J, Guo Z, Duan L, Zhang J, Yu R.   +8 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source