Results 91 to 100 of about 8,493,857 (289)

Evaluation of the Early Years South Australia mobile application

BMC Public Health
Background Released in July 2023 by the Office for Early Child Development in South Australia (SA), the Early Years SA mobile app supports parents of children aged 0–5 years with features including health check reminders, developmental milestone ...
Ben Singh, Kate Walker, Joann Fildes, Jessica Morley, Kylie Dankiw, Ty Ferguson, Rachel Curtis, Jacinta Brinsley, Carol Maher   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Task-Evoked Dynamic Network Analysis Through Hidden Markov Modeling

Frontiers in Neuroscience, 2018
Complex thought and behavior arise through dynamic recruitment of large-scale brain networks. The signatures of this process may be observable in electrophysiological data; yet robust modeling of rapidly changing functional network structure on rapid ...
Andrew J. Quinn, Andrew J. Quinn, Diego Vidaurre, Diego Vidaurre, Romesh Abeysuriya, Romesh Abeysuriya, Robert Becker, Robert Becker, Anna C. Nobre, Anna C. Nobre, Anna C. Nobre, Mark W. Woolrich, Mark W. Woolrich   +12 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Long-range temporal correlations in resting state alpha oscillations in major depressive disorder and obsessive-compulsive disorder

Frontiers in Neuroinformatics
IntroductionMental disorders are a significant concern in contemporary society, with a pressing need to identify biological markers. Long-range temporal correlations (LRTC) of brain rhythms have been widespread in clinical cohort studies, especially in ...
Ekaterina Proshina, Olga Martynova, Olga Martynova, Galina Portnova, Guzal Khayrullina, Guzal Khayrullina, Olga Sysoeva, Olga Sysoeva   +7 more
doaj   +1 more source

SOME MICRO ASPECTS OF HUMAN MIGRATION ACTIVITY [PDF]

Labor and Human Capital,
Osburn, David D.
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Does diet strictness level during weekends and holiday periods influence 1-year follow-up weight loss maintenance? Evidence from the Portuguese Weight Control Registry

Nutrition Journal, 2019
There is not much evidence about how diet strictness during weekends and holidays influence long-term weight loss maintenance. Our aim was to examine how dieting more or less strictly during weekends and holidays (vs.
Rui Jorge, Inês Santos, Vitor Hugo Teixeira, Pedro Jorge Teixeira   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source