Results 121 to 130 of about 16,739,739 (312)

Effect of Summer Holiday Programs on Children’s Mental Health and Well-Being: Systematic Review and Meta-Analysis

Children
Poor youth mental health is an area of global concern. Summer holiday programs may provide environments that support mental health when the structures and supports of school are not available.
Emily Eglitis, Catherine Simpson, Ben Singh, Timothy Olds, Amanda Machell, Rosa Virgara, Mandy Richardson, Kylie Brannelly, Aniella Grant, Jessica Gray, Terri Wilkinson, Zoe Rix, Carol Maher   +12 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Voluntary Attention Assessing Tests in Children with Neurodevelopmental Disorders Using Eye Tracking

Children
Background/Objectives: The development of techniques for assessing cognitive functions using eye tracking is particularly important for children with developmental disabilities.
Anna Rebreikina, Dmitry Zakharchenko, Antonina Shaposhnikova, Nikita Korotkov, Yuri Klimov, Tatyana Batysheva   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Exploring plausible futures for artificial intelligence in rural healthcare: insights from participatory foresight methods

Frontiers in Digital Health
BackgroundArtificial intelligence (AI) has the potential to transform rural healthcare delivery through automated monitoring, personalised care, and virtual support. Yet the future pathways for AI in rural contexts remain underexplored.
Tara Cain, Rachel Curtis, Ben Singh, Ashleigh E. Smith, Jacinta Brinsley, Carol Maher, Aaron Davis   +6 more
doaj   +1 more source

Exploring the relationship between physical activity knowledge, health outcomes expectancies, and behavior [PDF]

, 2011
Background: Despite clear health benefits of physical activity, previous research has been limited in linking knowledge of physical activity recommendations to actual behavior.
Bauman, Adrian, Heinrich, Katie M., Maddock, Jay E.   +2 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Homologues of human macrophage migration inhibitory factor from a parasitic nematode gene cloning protein activity and crystal structure

, 2002
Cytokines are the molecular messengers of the vertebrate immune system, coordinating the local and systemic immune responses to infective organisms. We report here functional and structural data on cytokine-like proteins from a eukaryotic pathogen.
Scott AL, Wang JM, Maizels, Rick M, Maizels RM, Taylor P, Wang, Ji Ming, Meyer, David J, Taylor, Paul, Scott, Alan L, Zang XX, Meyer DJ, Walkinshaw, Malcolm D, Walkinshaw MD, Zang, Xingxing   +13 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source