Results 101 to 110 of about 35,510 (163)

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Hepatic Overexpression of Lysophospholipid Acyltransferase LPLAT14/MBOAT1 Ameliorates Mild Liver Injury During Early High‐Fat Diet Feeding [PDF]

FASEB Bioadv
Using an improved adenovirus vector, we investigated the effects of hepatic LPLAT14 overexpression on high‐fat diet (HFD)‐induced metabolic disorders and mild liver injury in mice. LPLAT14 selectively increased oleic acid (OA)‐containing phosphatidylserine (PS) species in the liver. This specific lipidomic remodeling attenuated mild liver injury during
Hori S, Shimizu K, Kikuchi T, Miyata H, Hase H, Nakanishi H, Shindou H, Mizuguchi H.   +7 more
europepmc   +2 more sources

Increased Expression of Desmin and Vimentin Impairs Mitochondrial Function and Reduces Contractility via G0S2 in Bladder Smooth Muscle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Our previous study demonstrated that elevated levels of desmin and vimentin reduce BSM contractility. This study shows that the reduced BSM contractility is associated with mitochondrial impairment. G0/G1 switch gene 2 (G0S2) is upregulated in desmin‐ and vimentin‐overexpressing BSM.
Elham Javed, Chellappagounder Thangavel, Karthik Thangavel, Joseph Hypolite, Isabelle Gamache, Yilin Wang, Sankar Addya, Darin Mak, Furqan Syed, Jyotsna Mishra, Vilas Desai, Pragnya Das, Dominic R. Villalba, Alok Bhushan, Shey‐Shing Sheu, Sunday A. Shoyele, Erin L. Seifert, Jose G. Teodoro, Steven S. An, Raymond B. Penn, Deepak A. Deshpande, Ettickan Boopathi   +21 more
wiley   +1 more source

Host Barriers to In Vivo HSC Gene Therapy with Helper-Dependent Adenovirus Vectors. [PDF]

Viruses
Anderson AK, Lieber A, Li C.
europepmc   +1 more source

Porcine Adenovirus-Based Viral Vectors for Swine Vaccines: A Scoping Review and Future Perspectives. [PDF]

Animals (Basel)
Sthitmatee N, Suanpat K, Sington Y, Muenthaisong A, Sangkakam K, Nambooppha B, Rittipornlertrak A, Apinda N, Koonyosying P, Varinrak T, Kreausukon K.   +10 more
europepmc   +1 more source

Intranasal Adenoviral Vector Vaccination Induces Durable Antibody and T Cell Responses in the Respiratory Tract. [PDF]

Vaccines (Basel)
Lee W, Lee J, Lee SM, Kim EH.
europepmc   +1 more source

One virus-many strategies: type-specific interactions between human adenoviruses and innate immunity. [PDF]

J Virol
Hanrieder L, Schreiner S.
europepmc   +1 more source

Preclinical Safety Evaluation of a Replication-Defective Canine Adenovirus Type 2 Vector-Based SARS-CoV-2 Vaccine Candidate in Murine Models. [PDF]

Vaccines (Basel)
Omara D, Ndekezi C, Mugaba S, Nakyanzi A, Natwijuka F, Kapaata A, Kato F, Byamukama D, Ggwaabya DE, Mugulusi O, Bwanga F, Katete DP, Matovu E, Olobo J, Obuku EA, Sande OJ, Serwanga J, Cose S, Kaleebu P, Balinda SN.   +19 more
europepmc   +1 more source

Upstream process optimization and its critical role in chimpanzee adenoviral vector clinical drug development: lessons learned from VRON-0200 manufacturing. [PDF]

Front Bioeng Biotechnol
Haut LH, Bennett J, MacDonald P.
europepmc   +1 more source

The immunogenicity and safety of adenoviral-based vaccines. [PDF]

Curr Opin Allergy Clin Immunol
Gardner J.
europepmc   +1 more source