Results 201 to 210 of about 7,610,427 (282)

AQP1 Corrects Acinar Cells’ Secretion Deficits in Sjögren's Disease

Oral Diseases, EarlyView.
ABSTRACT Introduction Sjögren's disease (SjD) is a systemic autoimmune disease characterized by dry mouth, dry eyes, and profound fatigue. Preclinical studies suggest that AQP1 gene expression in salivary glands corrects salivary hypofunction in preclinical and clinical studies of radiation‐induced xerostomia and improves salivary and lacrimal function
Paola Perez, Blake M. Warner, Youngmi Ji, Sandra Afione, Thomas J. F. Pranzatelli, Margaret E. Beach, Zohreh Khavandgar, Margie Grisius, Eileen Pelayo, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Alan N. Baer, John A. Chiorini   +12 more
wiley   +1 more source

Identification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10. [PDF]

PLoS Pathog
Mundy RM, Waraich K, Bates EA, Rizkallah PJ, Baker AT, Young MT, Morris E, da Fonseca PCA, Bliss CM, Matthews D, Bhella D, Parker AL.   +11 more
europepmc   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

CD46 is a cellular receptor for species D human adenovirus. [PDF]

mBio
Danskog K, Petersen F, Frängsmyr L, Gonzalez G, Becker M, Lenman A, Arnberg N.   +6 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

A randomized, observer-blind, phase 1 study of immune responses to three human adenovirus type 26 vector-based vaccines. [PDF]

EBioMedicine
Hertoghs N, Serroyen J, Tolboom J, van Heesbeen R, Ligtenberg N, Butler S, Merrall E, van Rosmalen M, Lavreys L, Maat-Ligthart M, McLean C, Luhn K, Hendriks J.   +12 more
europepmc   +1 more source

Development and characterization of neutralizing monoclonal antibodies against clinically relevant human adenovirus subgroup B serotypes. [PDF]

Virol Sin
Wang Y, Dou W, Chen Y, Liu K, Li M, Hoshino T, Jiang Y, Khrustalev VV, Churov AV, Orekhov AN, Zhao W, Li L, Yang Y, Shen C.   +13 more
europepmc   +1 more source

The lymphocyte function of allogeneic peripheral blood stem cell grafts is associated with relapse and cytomegalovirus reactivation

Transfusion, EarlyView.
Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment primarily for hematological malignancies. Infections, relapse, and graft versus host disease (GvHD) are some of the most common adverse events following HSCT. We aimed to evaluate whether the lymphocyte function of the stem cell graft was associated with these ...
Anna Söderström, Tengyu Wang, Johan Törlén, Hannes Lindahl, Davide Valentini, Stephan Mielke, Klara Asplund Högelin, Rebecca Axelsson Robertson, Michael Uhlin   +8 more
wiley   +1 more source

Current use of pre-clinical models for evaluation of human adenovirus-based cancer therapeutics. [PDF]

Mol Ther Oncol
Cole DK, Khanolkar RC, Davies JA, Gerry AB.   +3 more
europepmc   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source