Cell Proliferation, EarlyView.PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia +13 more
wiley +1 more source
Establishment of a Cynomolgus Macaque Model for Human Adenovirus Type 55-Induced Respiratory Disease. [PDF]
J Infect DisSeo SH +12 more
europepmc +1 more source
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
The FEBS Journal, EarlyView.Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
Correction: Prime-boost immunization with inactivated human adenovirus type 55 combined with an adjuvant enhances neutralizing antibody responses in mice. [PDF]
Virol JSeo SH +8 more
europepmc +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Molecular mechanisms of E1A splicing and innate immune suppression by human adenovirus
Human adenovirus (HAdV) is a collection of viral species (A through G) within the family adenoviridae that are associated with a wide variety of diseases including respiratory and gastrointestinal infections, as well as keratoconjunctivitis.
Graves, Drayson
core
Identification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10. [PDF]
PLoS PathogMundy RM +11 more
europepmc +1 more source
Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease
International Journal of Dermatology, EarlyView.Rodent exposure and aerosolized excreta can lead to hantavirus infection with systemic endothelial injury and capillary leak, resulting in thrombocytopenia and syndromes such as HPS/HCPS and HFRS/NE. Early dermatologic and mucosal findings, including flushing, conjunctival injection, petechiae/purpura, and mucosal bleeding, may provide important clues ...
Giuseppe Gallo +2 more
wiley +1 more source
A randomized, observer-blind, phase 1 study of immune responses to three human adenovirus type 26 vector-based vaccines. [PDF]
EBioMedicineHertoghs N +12 more
europepmc +1 more source