Results 121 to 130 of about 38,375 (244)

Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy [PDF]

, 2008
Currently the use of adenoviruses in cancer gene therapy is limited by efficient delivery of the virus into the tumour cells, detargeting of the virus from the liver, and the efficient spread of the virus within the tumour.
Kallioinen, Susanna E.
core  

Adenovirus-Mediated Expression of Dengue Virus 2 Envelope Ferritin Nanoparticles Induced Virus-Specific Immune Responses in BALB/c Mice

Microbiology Research
This study provides a preliminary background for the development of a viral vector vaccine for the dengue virus using genetic material encoded by dengue envelope ferritin nanoparticles.
M.S.B.W.T.M. Nipuna Sudaraka Tennakoon, Ji-Hoon Ryu, Yong-Sam Jung, Yingjuan Qian, Hyun-Jin Shin   +4 more
doaj   +1 more source

Role of homologous recombination/recombineering on human adenovirus genome engineering: Not the only but the most competent solution

Engineering Microbiology
Adenoviruses typically cause mild illnesses, but severe diseases may occur primarily in immunodeficient individuals, particularly children. Recently, adenoviruses have garnered significant interest as a versatile tool in gene therapy, tumor treatment ...
Lisa-Marie Dawson, Montaha Alshawabkeh, Katrin Schröer, Fatima Arakrak, Anja Ehrhardt, Wenli Zhang   +5 more
doaj   +1 more source

Systemic Infection with Enteric Adenovirus in Immunocompetent Child with Haemophilus influenzae Disease

Emerging Infectious Diseases, 2009
Nino Khetsuriani, Suxiang Tong, Xiaoyan Lu, Shannon Reed, Dean D. Erdman, Angela P. Campbell, Krongkaew Supawat, Sahas Liamsuwan, Narayanan Jothikumar, Sonja J. Olsen   +9 more
doaj   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Quantification of enterococci and human adenoviruses in environmental samples by real-time PCR [PDF]

, 2005
Pathogenic bacteria and enteric viruses can be introduced into the environment via human waste discharge. Methods for rapid detection and quantification of human viruses and fecal indicator bacteria in water are urgently needed to prevent human exposure ...
He, J W, Jiang, Sunny C
core  

Characterization of Human Adenoviruses of Medical Importance: Isolation of Infectious Virus from Clinical Specimens and Molecular Typing. [PDF]

Curr Protoc, 2023
Kajon AE, Lamson DM, George KS.
europepmc   +1 more source

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

Detection of human adenoviruses in influenza-negative patients with respiratory tract infections in Nanning, China. [PDF]

Virol J, 2023
Qin J, Yan T, Yin L, Yang C, Wang L, Qiu H, Hu Y, Xu B.   +7 more
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source