Results 41 to 50 of about 9,289,046 (328)

A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions

Cells, 2022
To develop adenoviral cell- or tissue-specific gene delivery, understanding of the infection mechanisms of adenoviruses is crucial. Several adenoviral attachment proteins such as CD46, CAR and sialic acid have been identified and studied.
Raphael L. Tsoukas, Wolfram Volkwein, Jian Gao, Maren Schiwon, Nora Bahlmann, Thomas Dittmar, Claudia Hagedorn, Eric Ehrke-Schulz, Wenli Zhang, Armin Baiker, Anja Ehrhardt   +10 more
doaj   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

Genotyping of human adenoviruses circulating in Southwest India. [PDF]

Virusdisease, 2016
Akhil C, Suresha PG, Sabeena S, Hindol M, Arunkumar G.   +4 more
europepmc   +2 more sources

Molecular evolution of human species D adenoviruses [PDF]

Infection, Genetics and Evolution, 2011
Adenoviruses are medium-sized double stranded DNA viruses that infect vertebrates. Human adenoviruses cause an array of diseases. Currently there are 56 human adenovirus types recognized and characterized within seven species (A-G). Of those types, a majority belongs to species D.
Christopher M, Robinson, Donald, Seto, Morris S, Jones, David W, Dyer, James, Chodosh   +4 more
openaire   +2 more sources

Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy

Biomedicines, 2019
Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the ...
Brennetta J. Crenshaw, Leandra B. Jones, Courtnee’ R. Bell, Sanjay Kumar, Qiana L. Matthews   +4 more
doaj   +1 more source

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses

Science Advances, 2017
Near-atomic resolution structure of species-D adenovirus 26 (HAdV-D26) reveals structural conservation among human adenoviruses. Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases and are also frequently used as gene ...
Xiaodi Yu, D. Veesler, M. Campbell, M. Barry, F. Asturias, M. Barry, V. Reddy   +6 more
semanticscholar   +1 more source

Chimpanzee Adenovirus Antibodies in Humans, Sub-Saharan Africa

Emerging Infectious Diseases, 2006
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses.
Zhiquan Xiang, Yan Li, Ann Cun, Wei Yang, Susan Ellenberg, William M. Switzer, Marcia L. Kalish, Hildegund C.J. Ertl   +7 more
doaj   +1 more source

Chimpanzee Adenoviruses Are Related to Four Subgenera of Human Adenoviruses

Intervirology, 1989
Nine adenovirus strains isolated from chimpanzees were studied with regard to their relatedness to each other and to human adenovirus prototypes by neutralization and hemagglutination inhibition. The strains belonged to six serotypes, and all of them were clearly related to, but not identical to human adenoviruses of subgenus A, B, C, or E respectively.
R, Wigand, M, Mauss, T, Adrian
openaire   +2 more sources

Chimpanzee adenoviral vectors as vaccines – challenges to move the technology into the fast lane

Expert Review of Vaccines, 2017
Introduction: In recent years, replication-defective chimpanzee-derived adenoviruses have been extensively evaluated as genetic vaccines. These vectors share desirable properties with human adenoviruses like the broad tissue tropism and the ease of large-
Alessandra Vitelli, Antonella Folgori, Elisa Scarselli, Stefano Colloca, Stefania Capone, Alfredo Nicosia   +5 more
doaj   +1 more source