Results 211 to 220 of about 2,004,606 (267)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Basic Fibroblast Growth Factor Induces Matrix Metalloproteinase-13 via ERK MAP Kinase-Altered Phosphorylation and Sumoylation of Elk-1 in Human Adult Articular Chondrocytes [Expression of Concern]. [PDF]

Open Access Rheumatol
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Neurogenesis in adult human

NeuroReport, 1996
This report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not glial proteins.
Murrell, Wayne, Bushell, Gillian R., Livesey, Jonathon, McGrath, John, MacDonald, Kelli P.A., Bates, Paul R., Mackay Sim, Alan   +6 more
openaire   +3 more sources

Adult Human Thyroid Weight

Health Physics, 1985
The weights and dimensions of approximately 1400 normal human thyroid glands were taken at autopsy by the King County Medical Examiner's Office (Seattle, WA) over a two-year period ending in the spring of 1981. The values for thyroid gland weight observed in this data set were compared statistically with those presented by Mochizuki, Mowafy, and ...
B G, Pankow, J, Michalak, M K, McGee
openaire   +2 more sources

Adult human amino acid requirements

Current Opinion in Clinical Nutrition and Metabolic Care, 1999
This brief review is concerned with the status of our current understanding of the quantitative needs for dietary amino acids in healthy adults. The nutritional significance of the conditionally indispensable amino acids is assessed and the requirements for the indispensable amino acids are discussed.
V R, Young, S, Borgonha
openaire   +2 more sources

TOXOPLASMOSIS IN THE HUMAN ADULT

Archives of Internal Medicine, 1952
HUMAN toxoplasmosis has been recognized with increasing frequency since the first description of the disease by Janku 1 in 1923 and the demonstration by Wolf, Cowen, and Paige 2 of Toxoplasma as a cause of congenital encephalomyelitis with hydrocephalus, intracerebral calcifications, microcephaly, chorioretinitis, and microphthalmos.
E H, KASS, S B, ANDRUS, R D, ADAMS, F C, TURNER, H A, FELDMAN   +4 more
openaire   +2 more sources

The human adult cardiomyocyte phenotype

Cardiovascular Research, 2003
Determination of the phenotype of adult human atrial and ventricular myocytes based on gene expression and morphology.Atrial and ventricular cardiomyocytes were obtained from patients undergoing cardiac surgery using a modified isolation procedure. Myocytes were isolated and cultured with or without serum.
Bird, SD, Doevendans, PA, van Rooijen, MA, de la Riviere, AB, Hassink, RJ, Passier, R, Mummery, CL   +6 more
openaire   +3 more sources