Results 211 to 220 of about 2,152,983 (311)

Modeling hepatic steatosis with human adult stem cell-derived liver organoids. [PDF]

iScience
Zhu L, Liu S, Wang Z, Yang Y, Han P, Tong W, Zhao T, Wang L, Cui T, Yang L, Zhang Y.   +10 more
europepmc   +1 more source

3D organic bioelectronics for electrical monitoring of human adult stem cells.

Mater Horiz, 2023
Savva A, Saez J, Withers A, Barberio C, Stoeger V, Elias-Kirma S, Lu Z, Moysidou CM, Kallitsis K, Pitsalidis C, Owens RM.   +10 more
europepmc   +1 more source

Predicting multipotency of human adult stem cells derived from various donors through deep learning. [PDF]

Sci Rep, 2022
Kim H, Park K, Yon JM, Kim SW, Lee SY, Jeong I, Jang J, Lee S, Cho DW.   +8 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Disappearance of Acquired Hemophilia A after Complete Remission in a Multiple Myeloma Patient

Turkish Journal of Hematology, 2017
Vanessa Innao, Alessandro Allegra, Rosalba Morreale, Sabina Russo, Caterina Musolino   +4 more
doaj   +1 more source

Tert-Butyl Hydroperoxide in Human Adult Mesenchymal Stem Cells Isolated from Dermis: A Stress-Induced Premature Senescence Model. [PDF]

Cells
Pampanella L, Petrocelli G, Abruzzo PM, Tassinari R, Bassoli B, Sgarzani R, Maioli M, Ventura C, Canaider S, Facchin F.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices. [PDF]

Curr Protoc
Lodrini AM, Groeneveld EJ, Palmen M, Hjortnaes J, Smits AM, Goumans MJ.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Characterisation of Mesenchymal Stromal Cells (MSCs) from Human Adult Thymus as a Potential Cell Source for Regenerative Medicine. [PDF]

J Clin Med
Ramsperger-Gleixner M, Li C, Wallon N, Kuckhahn A, Weisbach V, Weyand M, Heim C.   +6 more
europepmc   +1 more source