Results 191 to 200 of about 2,152,983 (311)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity. [PDF]

Cell Press Blue
Matuck BF, Huynh KLA, Pereira D, Easter QT, Zhang X, Kunz M, Kumar N, Pratapa A, Rupp BT, Ghodke A, Predeus AV, Fernandes A, Szabó L, Hartmann S, Harnischfeger N, Khavandgar Z, Beach M, Perez P, Nilges B, Moreno MM, Ko KI, Singh R, Tata PR, Teichmann SA, Kimple A, Pringle S, Kretzschmar K, Warner BM, Sequeira I, Liu J, Byrd KM.   +30 more
europepmc   +1 more source

Scattered Tubular Cells Markers in Macula Densa of Normal Human Adult Kidney. [PDF]

Int J Mol Sci, 2022
Tossetta G, Fantone S, Lorenzi T, Galosi AB, Sagrati A, Fabri M, Marzioni D, Morroni M.   +7 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice. [PDF]

NPJ Regen Med
Bouhamida E, Vadakke-Madathil S, Mathiyalagan P, Ranjan AK, Khan A, Sherman CD, Miller PE, Ghetti A, Abi-Gerges N, Chaudhry HW.   +9 more
europepmc   +1 more source

Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis. [PDF]

Cells, 2021
Nath A, Rayabaram J, Ijee S, Bagchi A, Chaudhury AD, Roy D, Chambayil K, Singh J, Nakamura Y, Velayudhan SR.   +9 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids. [PDF]

EMBO Rep
Vassalou S, Lalioti ME, Di Giaimo R, Taraviras S, Cappello S, Kyrousi C.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Adult learners versus policies: An insight of adult education in the UK

, 2012
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University on 23 Nov 2012.This research evaluates adult education policies under the UK’s New Labour Government between 1997 and 2010.
Farhan, Dhuha
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