Results 51 to 60 of about 25,437 (212)
ChemistryOpen, EarlyView.Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Esther R. S. Paz +8 more
wiley +1 more source
Plasma neuronal specific enolase : a potential stage diagnostic marker in human African trypanosomiasis [PDF]
, 2014 © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Mitchell, Julia A, Sternberg, Jeremy M
core +1 more source
Integrative Zoology, EarlyView.Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li +5 more
wiley +1 more source
Molecular epidemiology of African sleeping sickness [PDF]
, 2009 Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT +5 more
core +2 more sources
Trypanocidal and leishmanicidal activity of six limonoids [PDF]
, 2020 Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma ...
A-E Hay +30 more
core +3 more sources
Tropical Medicine and Infectious Disease, 2020 Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Srinivasa P S Rao +13 more
doaj +1 more source
Impact of pulmonary African trypanosomes on the immunology and function of the lung
Nature Communications, 2022 A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Dorien Mabille +14 more
doaj +1 more source
Equine trypanosomiasis, a systematic review and meta‐analyses: Prevalence, morbidity and mortality
Equine Veterinary Journal, EarlyView.Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Alexandra G. Raftery +5 more
wiley +1 more source
Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria [PDF]
, 2016 Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis.
Ciosi, Marc +8 more
core +1 more source
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
PLoS Neglected Tropical Diseases, 2018 We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum.
Lori Ferrins +11 more
doaj +1 more source