Results 61 to 70 of about 11,156 (164)

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Masaki Ishida, Shuichi Ueno, Takashi Tominaga, Kurumi Tanaka, Akito Horikawa, Manabu Hori   +5 more
wiley   +1 more source

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Human African trypanosomiasis control: Achievements and challenges.

PLoS Neglected Tropical Diseases, 2017
Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa.
Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele   +4 more
doaj   +1 more source

African trypanosomes

Parasites & Vectors, 2019
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews   +4 more
doaj   +1 more source

Diversity of human African trypanosomiasis epidemiological settings requires fine-tuning control strategies to facilitate disease elimination

Research and Reports in Tropical Medicine, 2013
PP Simarro,1 JR Franco,1 A Diarra,2 JA Ruiz Postigo,3 J Jannin11World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Regional Office for Africa,
Simarro PP, Franco JR, Diarra A, Ruiz Postigo JA, Jannin J   +4 more
doaj  

Metabolomic profiling for the identification of drug targets in trypanosomes

Frontiers in Chemical Biology
Trypanosomes belong to a group of unicellular flagellated eukaryotes which include species responsible for serious, potentially fatal human diseases, mainly occurring in tropical and subtropical regions of the world: Trypanosoma brucei for sleeping ...
Maura Rojas-Pirela, Maura Rojas-Pirela, Maura Rojas-Pirela, Maura Rojas-Pirela, Diego Andrade-Alviárez, Wilfredo Quiñones, Ana J. Cáceres, Melisa Gualdrón-López, Ariel M. Silber, Ariel M. Silber, Paul A. M. Michels, Paul A. M. Michels   +11 more
doaj   +1 more source

The burden and spatial distribution of bovine African trypanosomes in small holder crop-livestock production systems in Tororo District, south-eastern Uganda

Parasites & Vectors, 2014
Background African animal trypanosomiasis (AAT) is considered to be one of the greatest constraints to livestock production and livestock-crop integration in most African countries.
Dennis Muhanguzi, Kim Picozzi, Jan Hattendorf, Michael Thrusfield, John David Kabasa, Charles Waiswa, Susan Christina Welburn   +6 more
doaj   +1 more source

The importance of veterinary policy in preventing zoonoses emergence and re-emergence: Examining the case of Human African Trypanosomiasis in Uganda

Frontiers in Public Health, 2014
Rapid changes in human behaviour, resource utilisation and other extrinsic environmental factors continue to threaten the current distribution of several endemic and neglected zoonoses worldwide.
Anna L Okello, Susan C Welburn
doaj   +1 more source

Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T. b. gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa

Bulletin of the World Health Organization, 2002
OBJECTIVE: To evaluate the performance of serological tests using dried blood on filter-papers (micro-card agglutination test for trypanosomiasis (micro-CATT)) performed under field and laboratory conditions and using whole blood ((CATT/T.b.
Truc Philippe, Lejon Veerle, Magnus Eddy, Jamonneau Vincent, Nangouma Auguste, Verloo Didier, Penchenier Laurent, Büscher Philippe   +7 more
doaj  

Cost analysis of options for management of African Animal Trypanosomiasis using interventions targeted at cattle in Tororo District; south-eastern Uganda

Parasites & Vectors, 2015
Background Tsetse-transmitted African trypanosomes cause both nagana (African animal Trypanosomiasis-AAT) and sleeping sickness (human African Trypanosomiasis - HAT) across Sub-Saharan Africa.
Dennis Muhanguzi, Walter O. Okello, John D. Kabasa, Charles Waiswa, Susan C. Welburn, Alexandra P.M. Shaw   +5 more
doaj   +1 more source