Results 61 to 70 of about 13,726 (210)
Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle
Evolutionary Applications, Volume 19, Issue 6, June 2026.ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic data, can be employed to ...
Gillian P. McHugo +10 more
wiley +1 more source
Trypanosomiasis vector control in Africa and Latin America. [PDF]
, 2008 Vectors of trypanosomiasis - tsetse (Glossinidae) in Africa, kissing-bugs (Triatominae) in Latin America - are very different insects but share demographic characteristics that render them highly vulnerable to available control methods.
Schofield, Chris J +3 more
core +1 more source
Tropical Medicine and Infectious Disease, 2020 Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Srinivasa P S Rao +13 more
doaj +1 more source
Impact of pulmonary African trypanosomes on the immunology and function of the lung
Nature Communications, 2022 A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Dorien Mabille +14 more
doaj +1 more source
Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 9, 14 May 2026.New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira +7 more
wiley +1 more source
Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]
, 2012 Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
MacLean, L. +19 more
core +1 more source
Parasite, 2020 This study aimed to identify trypanosomes infecting cattle in Malawi in order to understand the importance of cattle in the transmission dynamics of Human African Trypanosomiasis (HAT) and Animal African Trypanosomosis (AAT).
Marsela Megasari +8 more
doaj +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
Therapy of Human African Trypanosomiasis: Current Situation
Memorias do Instituto Oswaldo Cruz, 1999 This paper is a review of the current situation of the treatment of human African trypanosomiasis. The existing approved drugs are old, toxic and/or expensive. Therapeutic failures are common.
Jorge Atouguia, José Costa
doaj +1 more source
Tick‐borne pathogen interactions enhance transmission in cattle and ticks in Ogun, Nigeria
Ecosphere, Volume 17, Issue 5, May 2026.Abstract Tick‐borne diseases (TBDs) pose a major public health concern in tropical regions, where co‐infections and pathogen interactions complicate disease control. Understanding how these interactions vary across vertebrate hosts and tick vectors, and their impact on disease transmission, is crucial for developing effective intervention strategies ...
Foluke Adedayo Akande +15 more
wiley +1 more source