Results 61 to 70 of about 24,248 (200)
Poor husbandry practices in Bukombe District accelerate diseases in livestock and indiscriminate uses of antimicrobials. Cow abortions, raw cow placenta and aborted fetuses feeding dogs, communal grazing and watering and introduction of new animals predict brucellosis in the herd.
Makoye Mhozya +2 more
wiley +1 more source
Background: Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-
Julianne Meisner +2 more
doaj +1 more source
Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe +6 more
wiley +1 more source
Risk for Human African Trypanosomiasis, Central Africa, 2000–2009
Comprehensive georeference records for human African trypanosomiasis in Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea, and Gabon were combined with human population layers to estimate a kernel-smoothed relative risk function.
Pere P. Simarro +8 more
doaj +1 more source
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou +9 more
wiley +1 more source
ABSTRACT Background and Aims An unknown disease known as Disease X first surfaced in the Panzi Health Zone, Kwango Province, Democratic Republic of the Congo (DRC), towards the end of 2024. It mainly affected children under the age of five. The clinical characteristics and of the outbreak are examined in this review.
Muhammad Shaheer Bin Faheem +2 more
wiley +1 more source
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Srinivasa P S Rao +13 more
doaj +1 more source
Impact of pulmonary African trypanosomes on the immunology and function of the lung
A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Dorien Mabille +14 more
doaj +1 more source
Trypanocidal and leishmanicidal activity of six limonoids [PDF]
Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma ...
A-E Hay +30 more
core +3 more sources
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret +9 more
wiley +1 more source

