Results 81 to 90 of about 13,726 (210)

In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness

, 2012
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Kisala, M, Schmid, C., Kisala, M., Mordt, O. V., Ismael Lumpungu, Mutanda, S, Mays Kisala, Kande, V, Nganzobo Pathou, Kuemmerle Andrea, Blum Johannes, Medard Ilunga, Nono Mubwa, Lumpungu Ismael, Mubwa Nono, Mordt Olaf Valverde, Schmid Caecilia, Mubwa, N, Blesson Severine, Wilfried Mutombo, Nganzobo, P., Mutombo Wilfried, Victor Kande, Mordt, O V, Tete Digas, Tete, D, Blesson, S, Kümmerle, A., Ilunga Medard, Schmid, C, Ilunga, M., Kuemmerle, A, Sylvain Mutanda, Ghabri, S, Ghabri, S., Andrea Kuemmerle, Lumpungu, I, Salah Ghabri, Kande, V., Johannes Blum, Lumpungu, I., Ghabri Salah, Blum, J, Digas Tete, Mubwa, N., Mutanda, S., Pathou Nganzobo, Ilunga, M, Caecilia Schmid, Tete, D., Nganzobo, P, Blum, J., Mutombo, W., Mutanda Sylvain, Kisala Mays, Blésson, S., Olaf Valverde Mordt, Severine Blesson, Kande Victor, Mutombo, W   +59 more
core   +1 more source

Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. [PDF]

PLoS Neglected Tropical Diseases, 2016
Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa.
Jennifer A Gilbert, Jan Medlock, Jeffrey P Townsend, Serap Aksoy, Martial Ndeffo Mbah, Alison P Galvani   +5 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Accelerating towards human African trypanosomiasis elimination: Issues and opportunities

Journal of Vector Borne Diseases, 2020
Human African trypanosomiasis (HAT) has been an alarming global public health issue. The disease affects mainly poor and marginalized people in low-resource settings and is caused by two subspecies of haemoflagellate parasite, Trypanosoma brucei and ...
Kingsley Uchenna Ozioko, Chris Ikem Okoye, Rose Nduka Obiezue, Idika Kalu Idika, Raymond Agbu Awudu, Bede Izuchukwu Ezewudo, Celestine Osita Ezea   +6 more
doaj   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis

, 2010
BackgroundThe persistent spread of Rhodesian human African trypanosomiasis (HAT) in Uganda in recent years has increased concerns of a potential overlap with the Gambian form of the disease.
Fevre, Eric M., Welburn Susan C., Peter M Atkinson, Kakembo, A.S., Peter W Gething, Kakembo, Abbas S. L., Susan C Welburn, Wardrop, Nicola A., Peter W. Gething, Picozzi, K., Picozzi, K, Atkinson Peter M., Nicola A. Wardrop, Gething, Peter W., Peter M. Atkinson, Susan C. Welburn, Fèvre Eric M., Picozzi, Kim, Kakembo, Abbas S.L., Kakembo, AS, Wardrop, N.A., Eric M. Fèvre, Gething, PW, Gething, P.W., Eric M Fèvre, Fèvre, EM, Kakembo, ASL, Wardrop Nicola A., Kakembo Abbas S. L., Wardrop, NA, Abbas S L Kakembo, Nicola A Wardrop, Welburn, SC, Atkinson, PM, Kim Picozzi, Picozzi Kim, Atkinson, Peter M., Welburn, Susan C., Atkinson, P.M., Abbas S. L. Kakembo, Gething Peter W.   +40 more
core   +1 more source

Mystery Disease X Outbreak in the Democratic Republic of the Congo: A Narrative Review of Epidemiological Patterns and Response Challenges

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims An unknown disease known as Disease X first surfaced in the Panzi Health Zone, Kwango Province, Democratic Republic of the Congo (DRC), towards the end of 2024. It mainly affected children under the age of five. The clinical characteristics and of the outbreak are examined in this review.
Muhammad Shaheer Bin Faheem, Muhammad Haroon‐Ul‐Rasheed, Sumaya Samadi   +2 more
wiley   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration.
Carol A. Olson (1807531), Mintwo, Alain Fukinsia, Deo, Gratias Kambau Manesa, Sonja C. Bernhard, Bilenge, Constantin Miaka Mia, Patrick Mangoni N'tombe, Pierre Nsele Mutantu (1807651), Gabriele Pohlig, Patrick Mangoni N’tombe (1807627), Sonja C Bernhard, Alain Fukinsia Mintwo, N'tombe, Patrick Mangoni, N’tombe, Patrick Mangoni, Stephen Macharia (1807624), Kuikumbi, Florent Mbo, Mpanya, Alain, Richard R. Tidwell, Alain Mpanya, Augustin Kayeye Munungi, Blum, Johannes, Gratias Kambau Manesa Deo, Alain Fukinsia Mintwo (1807636), Gabriele Pohlig, Richard R Tidwell, Pierre Nsele Mutantu, Constantin Miaka Mia Bilenge, Gratias Kambau Manesa Deo (1807630), Patrick Mangoni N’tombe, Alfred Mpoo Mpoto, Bernhard, Sonja C., Augustin Kayeye Munungi (1807645), Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Ndinga Dieyi Dituvanga, Sonja C. Bernhard (1807537), Ndinga Dieyi Dituvanga (1807648), Blaise Fungula Munungu, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Macharia, Stephen, Dituvanga, Ndinga Dieyi, Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Blaise Fungula Munungu (1807519), Mpoto, Alfred Mpoo, Christian Burri, Jose Ramon Franco, Jean-Pierre Fina Lubaki (1807546), Mutantu, Pierre Nsele, Franco, Jose Ramon, Johannes Blum, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Jose Ramon Franco (1807639), Carol A. Olson, Mesu, Victor Kande Betu Ku, Alfred Mpoo Mpoto (1807534), Stephen Macharia, Alain Mpanya (267142), Amadeu Dala, Johannes Blum (141240), Dala, Amadeu, Munungi, Augustin Kayeye, Victor Kande Betu Ku Mesu (1807510), Florent Mbo Kuikumbi (1807633), Amadeu Dala (1807642), Richard R. Tidwell (148409), Florent Mbo Kuikumbi, Jean-Pierre Fina Lubaki   +71 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source