Results 91 to 100 of about 13,726 (210)

Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis [PDF]

, 2008
Sleeping sickness is caused by a species of trypanosome blood parasite that is transmitted by tsetse flies. To understand better how infection with this parasite leads to disease, we provide here the most detailed description yet of the course of ...
Thuita, J.K., John K. Thuita, Mwangangi, D., C. M. R. Turner, Matovu, E., Masiga, D., Enock Matovu, Kagira John M., John K Thuita, Kagira, J.M., John M. Kagira, David Mwangangi, Turner, C.M.R., Thuita John K., Masiga Daniel, Mwangangi David, Matovu Enock, C M R Turner, Daniel Masiga, Turner C. M. R., John M Kagira   +20 more
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Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series [PDF]

, 2007
Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T. b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+ E) in Yumbe ...
Thomas, F, Legros, Dominique, Francesco Checchi, Patrice Piola, Thomas Florence, Ayikoru Harriet, Gerardo Priotto, Piola, P, Ayikoru, H, Piola, Patrice, Ayikoru, Harriet, Checchi Francesco, Legros, D, Thomas, Florence, Priotto Gerardo, Checchi, F, Priotto, Gerardo, Florence Thomas, Priotto, G, Checchi, Francesco, Legros Dominique, Dominique Legros, Harriet Ayikoru, Piola Patrice   +23 more
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Human African trypanosomiasis presenting at least 29 years after infection--what can this teach us about the pathogenesis and control of this neglected tropical disease? [PDF]

, 2014
No abstract ...
Francesco Checchi, Sarah Lawrence, Angela Vincent, Eligar, Vinay, Capewell, P, Pickrell, William Owen, William Owen Pickrell, Annette MacLeod, Checchi, Francesco, Shumonta Quaderi, Richard Walters, Darshan Sudarshi, Paul Capewell, Michael Brown, Brown, Michael, Alice Walker, MacLeod, Annette, Sudarshi, D, Sudarshi, Darshan, Walters, R, Eligar, V, Walters, Richard, Lawrence, Sarah, Walker, Alice, Caroline Clucas, Vincent, Angela, Vinay Eligar, Clucas, Caroline, Checchi, F, Macleod, A, Vincent, A, Capewell, Paul, Walker, A, Clucas, C, Quaderi, Shumonta, Lawrence, S, Quaderi, S, Brown, M, Pickrell, WO   +38 more
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African trypanosomes

Parasites & Vectors, 2019
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews   +4 more
doaj   +1 more source

Human African trypanosomiasis control: Achievements and challenges.

PLoS Neglected Tropical Diseases, 2017
Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa.
Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele   +4 more
doaj   +1 more source

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei. [PDF]

, 2013
Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many organisms including Trypanosoma brucei, the etiological agent of Human African Trypanosomiasis.
Harrison, Justin, Eskilsson, Susanne, van Aalten, Daan M. F., Collie, Iain T., Hopkins Navratilova, Iva, Ferguson, Michael A. J.; id_orcid, Navratilova, Iva Hopkins, Urbaniak, Michael D., Frearson, Julie A., Ferguson, Michael A J, Raimi, Olawale G., Aristotelous, Tonia, Urbaniak, Mick, Raimi, Olwale G., Fang, Wenxia   +14 more
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Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis.

, 2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
Chappuis, F, Udayraj, N, Meussen, A, Bovier, P A, Stietenroth, K   +4 more
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Early prediction of treatment efficacy in Second-Stage Gambiense Human African Trypanosomiasis

, 2012
Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies.
Chappuis, F., Bastard, M., Laurence Flevaud, Gerardo Priotto, Etard Jean-François, Flevaud, L., Jean-François Etard, Bastard Mathieu, Etard, Jean-François, Priotto Gerardo, Etard, J-F, Priotto, Gerardo, Priotto, G, Chappuis, F, Flevaud, L, Bastard, Mathieu, François Chappuis, Mathieu Bastard, Bastard, M, Priotto, G., Flevaud Laurence, Chappuis François, Chappuis, François, Flevaud, Laurence   +23 more
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Implications of heterogeneous biting exposure and animal hosts on Trypanosomiasis brucei gambiense transmission and control [PDF]

, 2015
The gambiense form of sleeping sickness is a neglected tropical disease, which is presumed to be anthroponotic. However, the parasite persists in human populations at levels of considerable rarity and as such the existence of animal reservoirs has been ...
Chitnis, Nakul, Nakul Chitnis (187823), Stone, Chris M., Nakul Chitnis, Chris M Stone, Chris M. Stone (802289)   +5 more
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