Results 61 to 70 of about 10,333 (209)

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

African trypanosomes

Parasites & Vectors, 2019
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews   +4 more
doaj   +1 more source

From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection

The FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley   +1 more source

Human African Trypanosomiasis: Epidemiology and Control

, 2006
Human African trypanosomiasis (HAT), or sleeping sickness, describes not one but two discrete diseases: that caused by Trypanosoma brucei rhodesiense and that caused by T. b. gambiense. The Gambian form is currently a major public health problem over vast areas of central and western Africa, while the zoonotic, Rhodesian form continues to present a ...
Fèvre, Eric M., Picozzi, K., Jannin, J., Welburn, S.C., Maudlin, I.   +4 more
openaire   +4 more sources

Iloprost treatment enhanced IL-4 signalling to reverse trypanosome-induced cognitive deficits and suppressed neuroinflammation in mice

International Journal of Infectious Diseases
Introduction: The development of neurological disorders following trypanosome brain infection has been recognised for over a century. However, an ongoing endeavour persists to comprehensively understand the neurocognitive and neuropathological changes ...
Dr Oluwashola Olaolu, Professor Hajierah Davids, Professor Gill. B Dealtry, Miss Oluwatoyin Morenikeji, Dr Emmanuel T Obishakin, Mrs Binta Iliayasu, Dr Azeez Idris, Dr Chris Duyilemi Ajonijebu   +7 more
doaj  

Epidemiology of Human Trypanosomiasis in Africa [PDF]

, 1965
P U CATALINO, Mario Stirpe, Vittorio Vanni   +2 more
openalex   +1 more source

The burden and spatial distribution of bovine African trypanosomes in small holder crop-livestock production systems in Tororo District, south-eastern Uganda

Parasites & Vectors, 2014
Background African animal trypanosomiasis (AAT) is considered to be one of the greatest constraints to livestock production and livestock-crop integration in most African countries.
Dennis Muhanguzi, Kim Picozzi, Jan Hattendorf, Michael Thrusfield, John David Kabasa, Charles Waiswa, Susan Christina Welburn   +6 more
doaj   +1 more source

The importance of veterinary policy in preventing zoonoses emergence and re-emergence: Examining the case of Human African Trypanosomiasis in Uganda

Frontiers in Public Health, 2014
Rapid changes in human behaviour, resource utilisation and other extrinsic environmental factors continue to threaten the current distribution of several endemic and neglected zoonoses worldwide.
Anna L Okello, Susan C Welburn
doaj   +1 more source

The six diseases WHO. Human trypanosomiasis in Africa. [PDF]

, 1981
Julie Foulkes
openalex   +1 more source