Results 161 to 170 of about 12,614,860 (303)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

When precision medicine meets human behavior: limits of artificial intelligence in predicting imatinib adherence. [PDF]

J Gastrointest Oncol
Kanda T.
europepmc   +1 more source

Characterizing the role of human behavior in the effectiveness of contact-tracing applications. [PDF]

Front Public Health, 2023
Fosch A, Aleta A, Moreno Y.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

AI assessment changes human behavior. [PDF]

Proc Natl Acad Sci U S A
Goergen J, de Bellis E, Klesse AK.
europepmc   +1 more source

Indoor and outdoor human behavior and myopia: an objective and dynamic study. [PDF]

Front Med (Lausanne), 2023
Harb EN, Sawai ES, Wildsoet CF.
europepmc   +1 more source

Other title: Employment Law's Clark Kent; Other title: ow You Can be a Superhero, Too!

, 2017
"7/7/2017."Kansas Human Rights Commission -- Harassment: Demonstrating "Reasonable Care" -- The Complaint Process -- The Investigation -- Disability: Engaging in the Interactive ...
Kansas Human Rights Commission.
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Barriers and Breakthroughs in U.S. Swine Biosecurity: A Key Informant Exploration of the Role of Human Behavior in Enhanced Biosecurity Compliance. [PDF]

Transbound Emerg Dis
Gelalcha BD, Chepkwony MC, Akinyede O, Das M, Yoder C, Perez A, Aguirreburualde MSP, Corzo C, Makau DN, Mahero MW.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source