Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Electrophoretic Behavior of Normal Human Serum Albumin at pH 4.0
, 1960 Karl Schmid, A. Polis
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
A human behavior-based model for respiratory infectious diseases prediction. [PDF]
Front Public HealthMa Z +6 more
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Influence of Human Behavior on COVID-19 Dynamics Based on a Reaction-Diffusion Model. [PDF]
Qual Theory Dyn Syst, 2023 Zhi S, Niu HT, Su YH, Han X.
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Classification of Human Decision Behavior: Finding Modular Decision Rules with Genetic Algorithms [PDF]
The understanding of human behavior in sequential decision tasks is important for economics and socio-psychological sciences. In search tasks, for example when individuals search for the best price of a product, they are confronted in sequential steps ...
Daniel Schunk +2 more
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GENERAL AND THEORETICAL: Human Nature and Collective Behavior: Papers in Honor of Herbert Blumer. TAMOTSU SHIBUTANI, ed [PDF]
, 1972 FORREST La VIOLETTE
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
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Adaptive human behavior and delays in information availability autonomously modulate epidemic waves. [PDF]
PNAS NexusMahmud MS +3 more
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