Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Variation in exposure in neighborhoods of Dhaka, Bangladesh across different environmental pathways: The influence of human behavior on fecal exposure in urban environments. [PDF]
Amin N +10 more
europepmc +1 more source
Exploring Large Digital Bodies for the Study of Human Behavior. [PDF]
Albuquerque UP +7 more
europepmc +1 more source
The impact of organizational culture and behavior on human resource management and on the performance of public and private companies, organizations and bodies: the case of the wood-furniture industry [PDF]
Δημήτριος Χ. Λεοντής +1 more
openalex
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Understanding Human Behavior: Examining the Dark Triad of Personality in the Light of Autism Spectrum Traits. [PDF]
Selçuk Özmen E, Koç AE.
europepmc +1 more source
Anisotropy of Human Horizontal and Vertical Navigation in Real Space: Behavioral and PET Correlates [PDF]
Andreas Zwergal +11 more
openalex +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source

