Results 61 to 70 of about 12,614,860 (303)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Cross-Species evidence for hippocampal CACNA1C as a therapeutic target for alcohol use disorder
Translational PsychiatryContext-induced relapse is a major barrier to recovery from alcohol use disorder (AUD). Identifying molecular targets involved in contextual memories associated with alcohol use may serve as novel pharmacotherapies.
Tanya Pareek +9 more
doaj +1 more source
The mediating effect of website quality on Internet searching behavior
, 2012 The study investigates the mediating effect of website quality on Internet searching behavior. The research model incorporates three dimensions, namely (1) Internet attitudes of the Internet users, (2) website quality, including the system quality ...
Ho, Li-an; Kuo, Tsung-hsien; Lin, Binshan +1 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Interactive exploration of neuroanatomical meta-spaces
Frontiers in Neuroinformatics, 2009 Large-archives of neuroimaging data present many opportunities for re-analysis and mining that can lead to new findings of use in basic research or in the characterization of clinical syndromes.
Shantanu H Joshi +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Tobacco use by Indian adolescents
Tobacco Induced Diseases, 2002 Adolescents are the most vulnerable population to initiate tobacco use. It is now well established that most of the adult users of tobacco start tobacco use in childhood or adolescence.
RK Chadda, SN Sengupta
doaj +1 more source
Introduction to human information behavior
, 2006 New Directions in Human Information Behavior, co-edited by Drs. Amanda Spink and Charles Cole provides an understanding of the new directions, leading edge theories and models in human information behavior.
Spink, Amanda H., Currier, James
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Emerging Evolutionary Approach to Human Information Behavior
, 2006 New Directions in Human Information Behavior, co-edited by Drs. Amanda Spink and Charles Cole provides an understanding of the new directions, leading edge theories and models in human information behavior.
Spink, Amanda H., Currier, James
core