Results 81 to 90 of about 5,199,515 (344)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Regulation of Human Behaviors

open access: yesFuture Neurology, 2007
The development of the frontal systems is a major evolutionary advancement of the human race. It enables the regulation of behaviors in accordance with goals and, hence, frees humans from the constraints imposed by our basic physiological instincts. The burgeoning neuroscience and neuropsychology literature has consistently highlighted the important ...
Lee, TMC, Leung, AWS, Chan, CCH
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Monkeys increase scratching when encountering unexpected good fortune

open access: yesScientific Reports
Elucidating how ancestral behavioural traits have been repurposed for psychological and social functions is critical to advancing our understanding of human behavioural evolution.
Sakumi Iki, Ikuma Adachi
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Robust Bayesian analysis of animal networks subject to biases in sampling intensity and censoring

open access: yesMethods in Ecology and Evolution
Data collection biases are a persistent issue for studies of social networks. This issue has been particularly important in animal social network analysis (ASNA), where data are often unevenly sampled and such biases may potentially lead to incorrect ...
Sebastian Sosa   +3 more
doaj   +1 more source

Primary Ewing's Sarcoma of Frontoparietal Bone with Major Soft Tissue Extension: An Unusual Presentation and Review of the Literature

open access: yesCase Reports in Pathology, 2012
An 11-year-old girl presented with progressively increasing swelling in scalp of 8-month duration with no neurological deficit. Local examination showed a hard swelling that seemed to be arising from frontal bone.
Anshu Gupta   +2 more
doaj   +1 more source

Gelatin Encapsulated Curcumin Nanoparticles Moderate Behavior of Human Primary Gingival Fibroblasts In Vitro [PDF]

open access: hybrid, 2020
Mai Thi-Hoang Nguyen   +4 more
openalex   +1 more source

Critique [of Implications for Survival: Coping Strategies of the Women in Alice Walker\u27s Novels by Robbie Jean Walker] [PDF]

open access: yes, 1987
Intersecting the tools of psychological and sociological research which attempt to explain real human behavior with the tools of the novelist which attempt to portray a fictional accounting of human behavior, Walker presents an analytical model for ...
Scott, Otis L.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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